수면 장애 환자에서 지속형 멜라토닌 제제의 임상적 사용에 대한 후향적 의무기록 리뷰 연구
"A Retrospective Review on Clinical Use of Prolonged Release Melatonin in Patients With Sleep Disorders"
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"본 연구는 멜라토닌 지속형 제제의 실제 임상 처방 패턴을 분석함으로써, 성별, 연령, 최종 호전도에 따른 차이를 확인하고, 일부 환자군에서 단독 요법만으로도 긍정적 임상 반응이가능함을 보여주었다. 이는 멜라토닌의 실용적 가치와 맞춤형 수면치료 전략의 근거로 활용될 수 있으며, 향후 전향적 연구 를 통해 그 활용 가능성을 더욱 확장시킬 수 있을 것이다."
Abstract
Objectives: This study is a retrospective chart review of outpatients who were prescribed prolonged-release melatonin at a university hospital in Korea between January 5, 2015, and January 20, 2020. Methods: Descriptive statistics were conducted for all prescription cases as well as by primary diagnosis. Differences according to sex, age, and final clinical improvement were also examined. In addition, separate analyses were performed for cases where prolonged-release melatonin was prescribed as monotherapy. Results: A total of 1,764 cases were analyzed. Prescriptions were more common in females, with a mean age of 66.24 years. The most frequent primary diagnosis was insomnia. At the initial visit, symptom severity ranged from mild to moderate, and at the final visit, patients were generally minimally improved. A total of 866 cases involved prolonged-release melatonin prescribed as monotherapy, with a higher proportion of male patients. The initial symptom severity in these cases was milder than that of the overall prescription cases. Conclusion: These findings suggest the practical clinical utility of prolonged-release melatonin.