알코올의 진성 효과와 일부 인지 기능에 미치는 영향
Alcohol's Sedative Effect and the Effects on Some Cognitive Function
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알코올이 진정 작용(졸음)과 일부 인지 기능(집중력, 경계력, 단기 기억력)에 미치는 효과를 확인하기 위해서, 20세에서 28세 사이의 소위 건강한 정상인 대학생 지원자 15명을 대상으로 실험한 결과는 다음과 같다. 1. 알코올은 0.5g/kg 투여 시 1시간 후에, 1.0g/kg 투여 시 5시간까지 입면잠복기를 유의하게 단축시키는 효과가 있었다. 2. 알코올 0.5g/kg 은 투여 후 1시간까지, 1.0g/kg 은 투여 후 3시간까지 졸음과 피로감을 유발하였고, 기분에는 영향이 없었다. 3. 경계력은 알코올 1.0g/kg 투여 1시간 후에 유의하게 저하하였고, 주의 집중력과 단기 기억은 유의한 변화가 나타나지 않았다. 4. 알코올(0.5-1.0g/kg) 투여 시 졸음과 피로감, 피로감과 기분 사이에는 유의한 정 상관관계가 있었다. 이상의 결과를 요약하면, 정상인에서 알코올은 입면잠복기를 단축시키고 주간 졸음과 피로감을 유발하며, 경계력을 저하시키는 효과가 있음을 알 수 있었다.
Abstract
Objectives : The purpose of this study was to evaluate the effect of alcohol on sedation and some cognitive function (eg, daytime sleepiness, fatigue, and mood measured by multiple sleep latency test(MSLT) and visual analogue scale(VAS), vigilance, attention and short-term memory measured by Vienna Test System) Methods : 15 healthy, normal young college students participated in this study. Participating subjects were in good physical and psychological health and were asymptomatic as to sleep/wake complaints. Subjects visited our laboratory by 08:00 at the first day, and they had baseline MSLT and Test(at 9;00, 11;00, 14:00, and 16:00). Each time, the subjects completed VAS for sleepiness, fatigue and mood before they underwent an Vienna Test to evaluate their vigilance, attention and short-term memory. On the second day, subjects had 0.5g/kg of alcohol, the third day, subjects had 1.0g/kg of alcohol, and repeated the same process as those of the first Results : 0.5g/kg of alcohol reduced sleep latency after 1 hour, and 1.0g/kg of alcohol reduced sleep latency until 5 hours after administration significantly. 0.5g/kg of alcohol induced daytime sleepiness 1 hour after administration, and 1.0g/kg of alcohol induced daytime sleepiness and fatigue until 3 hours after administration, but there were no effects on mood. Vigilance was decreased significantly 1 hour after 0.5g/kg of alcohol administration, and attention and short-term memory were not changed significantly after alcohol administration. After alcohol administration(0.5-1.0g/kg), there were significant positive correlation between daytime sleepiness and fatigue, and fatigue and mood. Conclusion : It can be concluded that alcohol decreases sleep latency and induces daytime sleepiness and fatigue, and decreases vigilance in normal subjects.