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논문KCI 등재

한국인 청소년 재소자들의 충동성 및 공격성과 도파민 수송체 유전자 다형성의 연관성 연구

Association Study of the Impulsiveness and Aggressiveness in Adolescent Prisoners with Dopamine Transporter Gene Polymorphism

이종훈|최태영|성상율
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2012.04|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제18권 제1호|pp. 63-74|DOI http://dx.doi.org/

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충동성공격성도파민 수송체 유전자 다형성청소년 재소자Dopamine transporter gene (DAT1)PrisonersImpulsive aggression
주제분류정신과학

초록

Objectives: Impulsive aggression plays a critical role in the manifestation of violent and criminal behavior in adolescents and it also is a complex behavioral phenotype. The understanding brain mechanisms underlying impulsive aggression and identification of genetic risk factors is important to the prevention and treatment of impulsive aggression. Dopaminergic system plays an active role in the modulation of aggressive behaviors and hyperactivity in the dopamine system is associated with increases in impulsive aggression. We investigated the association of the impulsive aggression in Korean adolescent prisoners with DAT1 3'-untranslated region (UTR) variable number of tandem repeat (VNTR) polymorphism. Methods: We recruited 198 male adolescent prisoner volunteers and 68 healthy controls and investigated the dopamine transport gene (DAT1) polymorphisms. Impulsive symptoms were measured using Barratt Impulsiveness Scale (BIS) and Achenbach's Child Behavior Checklist (CBCL). We divided all subjects into three groups by BIS, and then we compared genetic frequency and allele frequency between each subgroup. Results: The distribution of the genotype in adolescent prisoners with 7/7, 9/10, 10/10, 10/11 were 7 (3.8%), 12 (6.6%), 158 (86.3%), 6 (3.3%) and the controls were 2 (3.2%), 5 (8.1%), 52 (83.9%), 3 (4.8%), respectively. No significant differences for genotype distribution were revealed between adolescent prisoners and normal controls. Also there was no significant difference of genotype distribution between subgroups. Conclusions: We failed to reveal the association between DAT1 polymorphism and impulsive aggression. In the future, larger sample size studies should continue to invest effort toward identifying the biological and genetic risk factors underlying impulsive aggression for developing effective treatment strategies.

Abstract

Objectives: Impulsive aggression plays a critical role in the manifestation of violent and criminal behavior in adolescents and it also is a complex behavioral phenotype. The understanding brain mechanisms underlying impulsive aggression and identification of genetic risk factors is important to the prevention and treatment of impulsive aggression. Dopaminergic system plays an active role in the modulation of aggressive behaviors and hyperactivity in the dopamine system is associated with increases in impulsive aggression. We investigated the association of the impulsive aggression in Korean adolescent prisoners with DAT1 3'-untranslated region (UTR) variable number of tandem repeat (VNTR) polymorphism. Methods: We recruited 198 male adolescent prisoner volunteers and 68 healthy controls and investigated the dopamine transport gene (DAT1) polymorphisms. Impulsive symptoms were measured using Barratt Impulsiveness Scale (BIS) and Achenbach's Child Behavior Checklist (CBCL). We divided all subjects into three groups by BIS, and then we compared genetic frequency and allele frequency between each subgroup. Results: The distribution of the genotype in adolescent prisoners with 7/7, 9/10, 10/10, 10/11 were 7 (3.8%), 12 (6.6%), 158 (86.3%), 6 (3.3%) and the controls were 2 (3.2%), 5 (8.1%), 52 (83.9%), 3 (4.8%), respectively. No significant differences for genotype distribution were revealed between adolescent prisoners and normal controls. Also there was no significant difference of genotype distribution between subgroups. Conclusions: We failed to reveal the association between DAT1 polymorphism and impulsive aggression. In the future, larger sample size studies should continue to invest effort toward identifying the biological and genetic risk factors underlying impulsive aggression for developing effective treatment strategies.

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