인터넷 중독 성향을 보이는 남자 청소년들의 기질 특성과 유전자 다형성
Temperament and Genetic Polymorphism in Korean Male Adolescents with Internet Addiction Tendency
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초록
행동중독의 한 유형이라고 볼 수 있는 인터넷중독성향 청소년들의 기질적 특성을 알아보고, 6개의 중독 후보유전자(5-HTTLPR/ DRD2 TaqI/DRD4/DAT1/COMT/NET)들의 유전자형과 대립유전자들의 빈도분포를 비교 분석한 결과, 청소년의 인터넷중독을 야기하는데에 Cloninger의 NS, HA 기질적인 요인이 관련되었고, 인터넷 중독성향군 내에서 유전자 다형성에 따른 기질 척도 점수를 비교한 결과, NET-8가 자극추구 점수와 연관성을 보였다. 향후 본 연구 결과에 대한 추시 및 보다 큰 집단을 대상으로 한 다양한 유전자형에 대한 체계적인 연구가 필요하다고 본다.
Abstract
Objectives：Among chemical and non-chemical dependence, internet addiction is one of the most frequent addictive behavior in adolescent. This study was performed to detect certain temperamental and genetic characteristics in adolescent with internet addiction tendency. Methods：87 adolescents with internet addiction tendency (AIT) and 78 adolescents without internet addiction tendency (NAIT) were classified by Young’s Internet Addiction Test. Cloninger’s Temperament Character Inventory and 6 candidate genes of drug addiction (DRD2 TaqI A, DRD4, DAT1, 5-HTTLPR, NET-8, and COMT) polymorphisms were tested between two groups. Results：Novelty Seeking scores (p=0.001) and Harm Avoidance scores (p=0.042) were significantly higher in AIT. The frequency of DRD2-A1/A1 genotype and G allele of NET-8 in AIT was higher than that in NAIT. In AIT, Novelty Seeking scores were significantly different (p=0.011) according to NET-8 genotypes (G/G>G/A>A/A). Conclusion：These data suggest that male adolescents with internet addiction tendency have the specific temperament and genetic polymorphisms like chemical dependence. (J Korean Neuropsychiatr Assoc 2006;45(5):468-475)
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