한국인 뚜렛 장애에서의 약물 반응과 도파민 유전자 다형상간의 상관관계에 대한 예비 연구
The Association between Medication Response and Dopaminergic Gene Polymorphism in Korean Children with Tourette Disorder
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목적: 본 연구는 도파민 관련 유전자와 뚜렛 장애아에서의 리스페리돈에 대한 반응간의 연관성을 알아보기 위한 목적으로 시행되었다. 방법: 서울대 병원 소아청소년 정신과 틱장애 클리닉에서 5-16세의 뚜렛 장애아 21명을 대상으로 하여 리스페리돈을 투여하고 이에 대한 반응에 따라 반응군과 비반응군으로 나눠 이 두군에서의 DRD3 (Ser9Gly), DRD4 (exon 3 VNTR), COMT (Val158Met)의 유전적 다형성을 분석하였다. 결과: 12명(57%)의 환아가 리스페리돈에 대한 반응군의 기준을 만족하였으며 나머지는 비반응군으로 분류되었다. DRD4와 COMT의 다형성에 있어서 리스페리돈 반응군과 비 반응군간에 유의한 차이를 보이지 않았으나, DRD3의 A allele과 AA 유전자형의 빈도가 리스페리돈 반응군에서 비반응군에 비해 유의하게 높게 나타났다. 결론: 이번 결과는 뚜렛 장애에서 DRD3 유전자와 리스페리돈에 대한 반응 사이에 유의한 연관성이 있을 가능성을 시사한다.
Abstract
Objectives: The purpose of this study is to explore association between the dopamine related gene and response to treatment with risperidone in children with Tourette disorder. Methods: Twenty-one children with Tourette disorder aged 5-16 were recruited from Tic Clinic at the Child and Adolescent Psychiatry Division of Seoul National University Hospital in Seoul, Korea. They were administered risperidone and grouped according to their responses. Response to risperidone was evaluated by psychiatrist using Yale Global Tic Severity Scale (YGTSS) and clinical observation. Polymorphism of three genetic markers including DRD3 (Ser9Gly), DRD4 (exon 3 VNTR), COMT (Val158Met) was analyzed in these risperidone compliant children with Tourette disorder. Association between genetic polymorphism and the response to risperidone was evaluated. Results: Twelve children (57%) showed response to risperidone and others were non-responders. Analysis showed no significant differences in DRD4 and COMT polymorphism between responders and nonresponders. However, frequencies of A allele and AA genotype of DRD3 were significantly higher in responders than in non-responders. Conclusion: Our results suggest that there may be a significant association between DRD3 gene and response to risperidone in Tourette disorder.
참고문헌 (20)
- "Pharmacogenetics of psychotropic drug response", 161(5), pp.780~796 (2004)
- "Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors", 2, pp.44~56 (1997)
- "The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders" (1991)
- "Tourette？s syndrome and homozygosity for the dopamine D3 receptor gene" (1993)
- "Polygenic inheritance of Tourette syndrome, stuttering, ADHD, conduct and oppositional defiant disorder", 67, pp.264~288 (1996)
- "Studies of the 48 bp Repeat Polymorphism of the DRD4 Gene in Impulsive, Compulsive, Addictive Behaviors", 88, pp.358~368 (1999)
- "Tourette syndrome and dopaminergic genes", 9(3), pp.272~277
- "The relation of the dopamine transporter gene to symptoms of internalizing disorders in children", 28(3), pp.215~225 (1998)
- "Human dopamine transporter gene", 5(3), pp.283~292 (2000)
- "Robertson MM, Gurling HM. The genetic susceptibility to Gilles de la Tourette syndrome in a large multiple affected British kindred", 37(8), pp.533~540 (1995)
- "Association between Tourette disorder and catechol-O-methyl transferase(COMT)gene in Korean subjects", 15, pp.178~184 (2004)
- "An accociation study between 5-HTTLPR polymorphism, COMT polymorphism, and Tourette？s syndrome", 97(2), pp.93~100 (2000)
- "Dopamine transporter genotype and methylphenidate dose response in children with ADHD", 7, pp.1374~1382 (2005)
- "Association between dopamine transporter and an enhanced response to methylphenidate in attention-deficit hyperactivity disorder", 12, pp.2290~2297 (2005)
- "Dopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate dose response in children with attention deficit hyperactivity disorder", 14(4), pp.564~574 (2004)
- "Dopamine D3 receptor Ser9Gly polymorphism and risperidone response", 25, pp.6~11 (2005)
- "Pharmacogenetics of treatment in first-episode schizophrenia", 15, pp.143~151 (2005)
- "Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia", 124B, pp.1~5 (2004)
- "Possible implication of the dopamine D3 receptor in schizophrenia and in antipsychotic drug actions", 31, pp.277~287 (2000)
- "Possible implication of the dopamine D3 receptor in schizophrenia and in antipsychotic drug actions", 31, pp.277~287 (2000)