Serotonin 2A Receptor Gene Polymorphism in Korean Children with Attention-Deficit/Hyperactivity Disorder
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초록
Objective The purpose of this study was to investigate the association between the T102C polymorphism in the serotonin 2A receptor gene and attention-deficit/hyperactivity disorder (ADHD) in Korean patients. Methods A total of 189 Korean children with ADHD as well as both parents of the ADHD children and 150 normal children participated in this study. DNA was extracted from blood samples from all of the subjects, and genotyping was conducted. Based on the allele and genotype information obtained, case-control analyses were performed to compare the ADHD and normal children, and Transmission disequilibrium tests (TDTs) were used for family-based association testing (number of trios=113). Finally, according to the significant finding which was showed in the case-control analyses, the results of behavioral characterastics and neuropsychological test were compared between ADHD children with and without the C allele. Results In the case-control analyses, statistically significant differences were detected in the frequencies of genotypes containing the C allele (χ2=4.73, p=0.030). In the family-based association study, TDTs failed to detect linkage disequilibrium of the T102C polymorphism associated with ADHD children. In the ADHD children, both the mean reaction time and the standard deviation of the reaction time in the auditory continuous performance test were longer in the group with the C allele compared to the group without the C allele. ConclusionaaThe results of this study suggest that there is a significant genetic association between the T102C polymorphism in the serotonin 2A receptor gene and ADHD in Korean children.
Abstract
Objective The purpose of this study was to investigate the association between the T102C polymorphism in the serotonin 2A receptor gene and attention-deficit/hyperactivity disorder (ADHD) in Korean patients. Methods A total of 189 Korean children with ADHD as well as both parents of the ADHD children and 150 normal children participated in this study. DNA was extracted from blood samples from all of the subjects, and genotyping was conducted. Based on the allele and genotype information obtained, case-control analyses were performed to compare the ADHD and normal children, and Transmission disequilibrium tests (TDTs) were used for family-based association testing (number of trios=113). Finally, according to the significant finding which was showed in the case-control analyses, the results of behavioral characterastics and neuropsychological test were compared between ADHD children with and without the C allele. Results In the case-control analyses, statistically significant differences were detected in the frequencies of genotypes containing the C allele (χ2=4.73, p=0.030). In the family-based association study, TDTs failed to detect linkage disequilibrium of the T102C polymorphism associated with ADHD children. In the ADHD children, both the mean reaction time and the standard deviation of the reaction time in the auditory continuous performance test were longer in the group with the C allele compared to the group without the C allele. ConclusionaaThe results of this study suggest that there is a significant genetic association between the T102C polymorphism in the serotonin 2A receptor gene and ADHD in Korean children.
참고문헌 (37)
- Franke B., "Genome-wide association studies in ADHD", Hum Genet, 126, pp.13~50 (2009)
- Purcell S., "Parental phenotypes in family-based association analysis", Am J Hum Genet, 76, pp.249~259 (2005)
- Spierman RS., "Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM)", Am J Hum Genet, 52, pp.506~516 (1993)
- Cho SC., "Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder", Am J Med Genet B Neuropsychiatr Genet, 147, pp.957~963 (2008)
- Cho SC., "Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample", Neurosci Lett, 446, pp.108~111 (2008)
- Halperin JM., "Serotonin, aggression, and parental psychopathology in children with attention-deficit hyperactivity disorder", Am Acad Child Adolesc Psychiatry, 36, pp.1391~1398 (1997)
- Halperin JM., "Age-related changes in the association between serotonergic function and aggression in boys with ADHD", Biol Psychiatry, 41, pp.682~689 (1997)
- Gainetdinov RR., "Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity", Science, 283, pp.397~401 (1999)
- Quist JF., "Genetics of childhood disorders XXIII. ADHD, Part 7: the serotonin system", J Am Acad Child Adolesc Psychiatry, 40, pp.253~256 (2001)
- O’Neill MF., "5-HT2 receptor antagonism reduces hyperactivity induced by amphetamine, cocaine, and MK-801 but not D1 agonist C-APB", Pharmacol Biochem Behav, 63, pp.237~243 (1999)
- Stahl SM., "Stahl’s Essential Psychopharmacology, 3rd Edition" (2008), Cambridge University Press
- Collier DA., "Association between 5-HT2A gene promoter polymorphism and anorexia nervosa", Lancet, 350, pp.412~ (1997)
- Erdmann J., "Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia", Hum Genet, 97, pp.614~619 (1996)
- Masellis M., "Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients", Neuropsychopharmacology, 19, pp.123~132 (1998)
- Quist JF., "Evidence for the serotonin HTR2A receptor gene as a susceptibility factor in attention deficit hyperactivity disorder (ADHD)", Mol Psychiatry, 5, pp.537~541 (2000)
- Hawi Z., "Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample", Mol Psychiatry, 7, pp.718~725 (2002)
- Zoroglu SS., "No evidence for an association between the T102C and 1438 G", A polymorphisms of the serotonin 2A receptor gene in attention deficit, Neuropsychobiology, pp.2003, 47[DOI]
- Li J., "Association of 5-HT(2A) receptor polymorphism and attention deficit hyperactivity disorder in children", Zhonghua Yi Xue Za Zhi, 82, pp.1173~1176 (2002)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders, 4th Edition" (1994), American Psychiatric Press
- 소유경, "한국어판 부모, 교사 ADHD 평가 척도의 신뢰도와 타당도 연구", 신경정신의학, 41(2) (2002), 대한신경정신의학회
- Sattler JM., "Assessment of Children’s Intelligence" (1974), WB Saunders Company
- Kaufman J., "Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Life Time Version (K-SADS-PL): initial reliability and validity data", J Am Acad Child Adolesc Psychiatry, 36, pp.980~988 (1997)
- Park M., "KEDI-WISC" (1987), Special Education Publishing Co
- Achenbach TM., "Manual for the Child Behavior Checklist", 4-18 and 1991 Profile, 1991
- Shin MS., "A study of the development and standarization of ADHD diagnostic system", Korean J Child Adolesc Psychiatry, 11, pp.91~99 (2000)
- Roman T., "Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit", hyperactivity disorder?, 2003, pp.120, 116~120
- Li J., "Serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder in Chinese Han subjects", Am J Med Genet B Neuropsychiatr Genet, 132, pp.59~63 (2005)
- Brookes K., "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes", Mol Psychiatry, 11, pp.934~953 (2006)
- Todd RD., "Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit", hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems, 2003, pp.8, 103~108
- Bjork JM., "Serotonin 2A receptor T102C polymorphism and impaired impulse control", Am J Med Genet, 114, pp.336~339 (2002)
- Cooley EL., "Attention in children: a neuropsychologically based model for assessment", Dev Neuropsychol, 6, pp.239~274 (1990)
- Bedi GC., "Investigation of modality-specific distractibility in children", Int J Neurosci, 74, pp.79~85 (1994)
- Keith RW., "Effect of methylphenidate on the auditory processing abilities of children with attention deficit-hyperactivity disorder", J Learn Dis, 24, pp.630~636 (1991)
- Lucker JR., "Perception of loudness in children with ADD and without ADD", Child Psychiatry Hum Dev, 26, pp.181~190 (1996)
- Ahveninen J., "Auditory selective attention modulated by tryptophan depletion in humans", Neurosci Lett, 340, pp.181~184 (2003)
- Findling RL., "Aripiprazole in children with attention-deficit", hyperactivity disorder, 2008, pp.28, 347~354
- Myung Ho Lim, "Aripiprazole in ADHD with Tic Disorder and in ADHD with Tourette Disorder: Two Case Reports", Clinical Psychopharmacology and Neuroscience, 5(2), pp.81~84 (2007), 대한정신약물학회
