세로토닌 수송체 조절부위 다형태와 청소년 재소자들의 충동성 및 공격성과의 연합연구
An Association Study of the Impulsiveness and Aggressiveness in Adolescent Prisoners with Serotonin Transporter Gene Promoter Region Polymorphism
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Abstract
Objectives：This study was carried out to explore the relationship between the impulsiveness and aggressiveness in adolescent prisoners and a polymorphism of the promoter region of the 5-HTT gene (5HTTLPR). Methods：198 adolescent prisoner volunleers and 68 male medical students as a normal control group were included in this study. The characteristics of adolescent prisoners and control subjects were assessed by using Barratt Impulsiveness Scale and Achenbach’s Child Behavior Checklist (CBCL). Genotypes of 5-HTTLPR were analysed with the primers flanking the regulatory region from genomic DNA. Results：Adolescent prisoners were significantly more aggressive (t=4.780, df=248, p<0.001), impulsive (t=5.220, df= 248, p<0.001), and delinquent (t=12.299, df=173.554, p<0.001) than control group. There were no statistically significant differences in genotype frequencies of 5-HTT between adolescent prisoners and control group (χ2=2.378, df=6, p=0.882). There were no statistically significant differences in allelic frequencies of 5-HTT between adolescent prisoners and control group (χ2=2.027, df=4, p=0.731). Conclusion：In view of the negative results in the association of the promoter region polymorphism of serotonin transporter and the characteristics of adolescent prisoner, the promoter region polymorphism dose not appear to be a candidate gene for the characteristics of adolescent prisoner group. Further systematic researches including varying variables of phenotype would be required. (J Korean Neuropsychiatr Assoc 2004;43(2):183-188)
참고문헌 (19)
- "경찰청 범죄통계(사회)" (2000), 조선일보
- "A survey of aggressivebehavior among a population of persons with intellectual disability inQueensland", 38, pp.369~381 (1994)
- "Psychopathology,biopsychological factors,crime and characteristicsand classification of 25 homicidal youth", 34, pp.1483~1489 (1995)
- "Psychiatric diagnosis in adolescentsex offenders", 27, pp.241~243 (1988)
- "Biologic correlates of suicidalrisk and aggressive behavior altraits", 12 (1992)
- "Cerebrospinal f1uid correlates of suicideattempts and aggression", 487 (1986)
- "Low versus highprolactin responders to fenfluramine challenge:maker of behavioraldifferences in adult male cynomolgus macaques", 9, pp.93~99 (1993)
- "Cerebrospinal fluid monoamine and adrenal correlates ofaggression in free-ranging Rhesus monkeys", 49, pp.436~441 (1992)
- "Low central nervous system serotonergic activityis traitlike and correlates with impulsive behavior:a nonhumanprimate model investigating genetic and environmental influences onneurotransmission", 836, pp.39~56 (1997)
- "Comparisonof cerebrospinal f1uid monoamine metabolite levels in dominantaggressiveand non-aggressive dogs", 7l4, pp.57~64 (1996)
- "5-HIAA in the cerebrospinal fluid:A biochemical suidide predictor", 33, pp.1193~1197 (1976)
- "Aggression and Violence: Genetic, Neurobiological,and Biosocial Perspectives" (1996)
- "Aggressionin humans correlates with cerebrospinal fluid amine metabolites", 1, pp.131~139 (1979)
- "Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrationdifferentiates impulsive from non-impulsive behavior", 33, pp.2609~2614
- "Blunted prolactine responses to D-fenfluramine in sociopathy:evidencefor subsensitivity of central serotonergic function", 160, pp.643~646
- "Association of aggressive behavior with altered serotonergicfunction in patients who are not suicidal", 157, pp.609~614 (2000)
- "Serotonergic studies in patients with affective and personalitydisorders:correlates with suicidal and impulsive aggressive behavior", 46, pp.587~599 (1989)
- "Allelicvariation of human serotonin transporter gene expression", 66, pp.2621~2624 (1996)
- "Reductionof 3H-imipramine binding sites on platelets of conduct disorderedchildren", 1, pp.55~62 (1987)