Influence of Myopia on Size of Optic Nerve Head and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography
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Purpose: To investigate optic nerve head size and retinal nerve fiber layer (RNFL) thickness according to refractivestatus and axial length. Methods: In a cross-sectional study, 252 eyes of 252 healthy volunteers underwent ocular biometry measurementas well as optic nerve head and RNFL imaging by spectral-domain optical coherence tomography. Correlationand linear regression analyses were performed for all subjects. The magnification effect was adjustedby the modified axial length method. Results: Disc area and spherical equivalent were positively correlated (r = 0.225, r2 = 0.051, p = 0.000). RNFLthickness showed significant correlations with spherical equivalent (r = 0.359, r2 = 0.129, p = 0.000), axiallength (r = -0.262, r2 = 0.069, p = 0.000), disc radius (r = 0.359, r2 = 0.129, p = 0.000), and radius of the scancircle (r = -0.262, r2 = 0.069, p = 0.000). After adjustment for the magnification effect, those relationships werereversed; RNFL thickness showed negative correlation with spherical equivalent and disc radius, and positivecorrelation with axial length and radius of the scan circle. The distance between the disc margin and the scancircle was closely correlated with RNFL thickness (r = -0.359, r2 = 0.129, p = 0.000), which showed a negativecorrelation with axial length (r = -0.262, r2 = 0.069, p = 0.000). Conclusions: Optic disc radius and RNFL thickness decreased in more severely myopic eyes, but they increasedafter adjustment for magnification effect. The error due to the magnification effect and optic nervehead size difference might be factors that should be considered when interpreting optical coherence tomographyresults.
Abstract
Purpose: To investigate optic nerve head size and retinal nerve fiber layer (RNFL) thickness according to refractivestatus and axial length. Methods: In a cross-sectional study, 252 eyes of 252 healthy volunteers underwent ocular biometry measurementas well as optic nerve head and RNFL imaging by spectral-domain optical coherence tomography. Correlationand linear regression analyses were performed for all subjects. The magnification effect was adjustedby the modified axial length method. Results: Disc area and spherical equivalent were positively correlated (r = 0.225, r2 = 0.051, p = 0.000). RNFLthickness showed significant correlations with spherical equivalent (r = 0.359, r2 = 0.129, p = 0.000), axiallength (r = -0.262, r2 = 0.069, p = 0.000), disc radius (r = 0.359, r2 = 0.129, p = 0.000), and radius of the scancircle (r = -0.262, r2 = 0.069, p = 0.000). After adjustment for the magnification effect, those relationships werereversed; RNFL thickness showed negative correlation with spherical equivalent and disc radius, and positivecorrelation with axial length and radius of the scan circle. The distance between the disc margin and the scancircle was closely correlated with RNFL thickness (r = -0.359, r2 = 0.129, p = 0.000), which showed a negativecorrelation with axial length (r = -0.262, r2 = 0.069, p = 0.000). Conclusions: Optic disc radius and RNFL thickness decreased in more severely myopic eyes, but they increasedafter adjustment for magnification effect. The error due to the magnification effect and optic nervehead size difference might be factors that should be considered when interpreting optical coherence tomographyresults.
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