Comparison of Retinal Layer Thicknesses of Highly Myopic Eyes and Normal Eyes
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Purpose: To evaluate the differences in individual segmental retinal layer thickness in adult patients with high myopia. Methods: This study compared the retinal layers of patients with high myopia (axial length of ≥26.0 mm) with those of normalcontrols using spectral-domain optical coherence tomography. The thicknesses of the retinal layers were compared usingnine Early Treatment Diabetic Retinopathy Study subfields. Choroidal thickness was also measured in the subfoveal area. Results: We included 37 eyes with high myopia and 37 eyes of healthy subjects. The mean age was 42.95 and 47.73 years (p =0.114), and the mean axial length was 27.28 and 24.47 mm (p < 0.001), respectively. The parafoveal areas (outer ring segment)of the ganglion cell layer and inner plexiform layer, all segmental areas except the subfoveal region of the inner nuclear layer,most segmental areas (inner superior, inner inferior, outer superior, outer temporal, and outer nasal) of outer plexiform layer,and most segmental areas (subfovea, inner temporal, inner inferior, inner nasal, outer temporal, and outer inferior) of outernuclear layer were thinner in eyes with high myopia than in normal eyes (all p < 0.05). There were no statistically significantdifferences between the levels of photoreceptor layer, retinal pigment epithelium, and nerve fiber layer. The mean choroidalthickness was 153.81 ± 64.80 and 239.54 ± 44.28 μm in the high myopia and control groups, respectively, which were significantlydifferent (p < 0.001). Conclusions: In high myopia without pathologic changes, there was a meaningful thinning of the retina and choroid, especiallyin most Early Treatment Diabetic Retinopathy Study subfield areas of the deep vascular complex, perifoveal area of thesuperficial vascular complex, and most areas of the outer nuclear layer in the outer retinal layer, which are associated withmyopic axial elongation.
Abstract
Purpose: To evaluate the differences in individual segmental retinal layer thickness in adult patients with high myopia. Methods: This study compared the retinal layers of patients with high myopia (axial length of ≥26.0 mm) with those of normalcontrols using spectral-domain optical coherence tomography. The thicknesses of the retinal layers were compared usingnine Early Treatment Diabetic Retinopathy Study subfields. Choroidal thickness was also measured in the subfoveal area. Results: We included 37 eyes with high myopia and 37 eyes of healthy subjects. The mean age was 42.95 and 47.73 years (p =0.114), and the mean axial length was 27.28 and 24.47 mm (p < 0.001), respectively. The parafoveal areas (outer ring segment)of the ganglion cell layer and inner plexiform layer, all segmental areas except the subfoveal region of the inner nuclear layer,most segmental areas (inner superior, inner inferior, outer superior, outer temporal, and outer nasal) of outer plexiform layer,and most segmental areas (subfovea, inner temporal, inner inferior, inner nasal, outer temporal, and outer inferior) of outernuclear layer were thinner in eyes with high myopia than in normal eyes (all p < 0.05). There were no statistically significantdifferences between the levels of photoreceptor layer, retinal pigment epithelium, and nerve fiber layer. The mean choroidalthickness was 153.81 ± 64.80 and 239.54 ± 44.28 μm in the high myopia and control groups, respectively, which were significantlydifferent (p < 0.001). Conclusions: In high myopia without pathologic changes, there was a meaningful thinning of the retina and choroid, especiallyin most Early Treatment Diabetic Retinopathy Study subfield areas of the deep vascular complex, perifoveal area of thesuperficial vascular complex, and most areas of the outer nuclear layer in the outer retinal layer, which are associated withmyopic axial elongation.
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