The Effects of Optic Disc Factors on Retinal Nerve Fiber Layer Thickness Measurement in Children
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: We analyzed the effect of the changes of the optic disc area (ODA) caused by the axial length and the refractive error, and the consequent changes of the distance from the optic disc margin to the circular scan (OD-CS) of Optical coherence tomography (OCT) on the measurement of the retinal nerve fiber layer thickness(RNFLT) were examined. Methods: One hundred two eyes of 51 children (age range 4 to 15 years) were measured using OCT including the RNFLT. For the ODA and the OD-CS, the relative area formed by the ODA and the circular scan was obtained. In addition, the correlation of the refractive error and the axial length to the optic disc factors was assessed. Results: As hyperopia progresses to myopia, the axial length became longer, the ODA became smaller (r=-0.442, p=0.000) and the OD-CS showed a tendency to increase (r=0.471, p=0.000). As the OD-CS became longer, the measured average RNFLT decreased significantly (r=-0.248, p=0.012), and the ODA and the OD-CS showed a significant correlation to the RNFL thickness that was measured in the nasal and inferior areas, the S2, N2 and N3 areas and the I1 area. Conclusions: As ODA becomes smaller and the OD-CS becomes longer, the RNFLT measured in the nasal and inferior areas, the S2, N2, N3, I1 area has a tendency to be thinner. Hence, consideration of the disc area is required when interpreting the RNFLT of these eyes.
Abstract
Purpose: We analyzed the effect of the changes of the optic disc area (ODA) caused by the axial length and the refractive error, and the consequent changes of the distance from the optic disc margin to the circular scan (OD-CS) of Optical coherence tomography (OCT) on the measurement of the retinal nerve fiber layer thickness(RNFLT) were examined. Methods: One hundred two eyes of 51 children (age range 4 to 15 years) were measured using OCT including the RNFLT. For the ODA and the OD-CS, the relative area formed by the ODA and the circular scan was obtained. In addition, the correlation of the refractive error and the axial length to the optic disc factors was assessed. Results: As hyperopia progresses to myopia, the axial length became longer, the ODA became smaller (r=-0.442, p=0.000) and the OD-CS showed a tendency to increase (r=0.471, p=0.000). As the OD-CS became longer, the measured average RNFLT decreased significantly (r=-0.248, p=0.012), and the ODA and the OD-CS showed a significant correlation to the RNFL thickness that was measured in the nasal and inferior areas, the S2, N2 and N3 areas and the I1 area. Conclusions: As ODA becomes smaller and the OD-CS becomes longer, the RNFLT measured in the nasal and inferior areas, the S2, N2, N3, I1 area has a tendency to be thinner. Hence, consideration of the disc area is required when interpreting the RNFLT of these eyes.
참고문헌 (26)
- Schuman JS, "Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography", Ophthalmology, 103, pp.1889~98 (1996)
- Jones AL, "The Humphrey optical coherence tomography scanner: quantative analysis and reproducibility study of the normal human retinal nerve fiber layer", Br J Ophthalmol, 85, pp.673~7 (2001)
- Blumenthal EZ, "Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography", Ophthalmology, 107, pp.2278~82 (2000)
- Carpineto P, "Reliability of nerve fiber layer thickness measurements using optical coherence tomography in normal and glaucomatous eyes", Ophthalmology, 110, pp.190~5 (2003)
- Salchow DJ, "Retinal nerve fiber layer thickness in normal children measured with optical coherence tomography", Ophthalmology, 113, pp.786~91 (2006)
- Huynh SC, "Peripapillary retinal nerve fiber layer thickness in a population of 6‐year‐old children: findings by optical coherence tomography", Ophthalmology, 113, pp.1583~92 (2006)
- Paunescu LA, "Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT", Invest Ophthalmol Vis Sci, 45, pp.1716~24 (2004)
- Quigley HA, "Larger optic nerve heads have more nerve fibers in normal monkey eyes", Arch Ophthalmol, 109, pp.1441~3 (1991)
- Jonas J.B, "Human optic nerve fiber count and optic disc size", Invest Ophthalmol Vis Sci, 33, pp.2012~8 (1992)
- Caprioli J, "Optic disc rim area is related to disc size in normal subjects", Arch Ophthalmol, 105, pp.1683~5 (1987)
- Budenz DL, "Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT", Ophthalmology, 114, pp.1046~52 (2007)
- Alamouti B, "Retinal thickness decreases with age: an OCT study", Br J Ophthalmol, 87, pp.899~901 (2003)
- 최성원, "Thickness Changes in the Fovea and Peripapillary Retinal Nerve Fiber Layer Depend on the Degree of Myopia", 대한안과학회지, 20(4), pp.215~219 (2006), 대한안과학회
- Hoh ST, "Optical coherence tomography and scanning laser polarimetry in normal, ocular hypertensive, and glaucomatous eyes", Am J Ophthalmol, 129, pp.129~35 (2000)
- 하성우, "한국인에서 광간섭단층촬영술 수치의 나이에 따른 차이", 대한안과학회지, 46(12), pp.2037~2044 (2005), 대한안과학회
- 송지혜, "광간섭단층촬영기로 측정한 소아의 망막신경섬유층 두께 및 시신경유두 분석", 대한안과학회지, 48(10), pp.1346~1353 (2007), 대한안과학회
- Johnson BM, "Age‐related decline of human optic nerve axon populations", Age, 20, pp.5~9 (1987)
- Asrani S, "Noninvasive mapping of the normal retinal thickness at the posterior pole", Ophthalmology, 106, pp.269~73 (1999)
- 정희진, "광간섭단층촬영(OCT3)의 Macular Map으로 측정한 정상인의 황반부 두께", 대한안과학회지, 45(6), pp.962~968 (2004), 대한안과학회
- Mikelberg FS, "Relation between optic nerve axon diameter to scleral canal area", Ophthalmology, 98, pp.60~3 (1991)
- Varma R, "Retinal nerve fiber layer thickness in normal human eyes", Ophthalmology, 103, pp.2114~9 (1996)
- 박성은, "시신경유두 크리에 따른 망막신경섬유층 분석", 대한안과학회지, 43(2), pp.395~401 (2002), 대한안과학회
- Leung CK, "Retinal nerve fiber layer measurements in myopia: An optical coherence tomography study", Invest Ophthalmol Vis Sci, 47, pp.5171~6 (2006)
- 최성원, "Thickness Changes in the Fovea and Peripapillary Retinal Nerve Fiber Layer Depend on the Degree of Myopia", 대한안과학회지, 20(4), pp.215~9 (2006), 대한안과학회
- Garcia‐Valenzuela E, "Thickness of the peripapillary retina in healthy subjects with different degrees of ametropia", Ophthalmology, 107, pp.1321~7 (2000)
- 김기형, "주사 레이저 편광측정계에 의한 한국 정상 성인의 망막신경섬유층 두께 분석", 대한안과학회지, 46(3), pp.442~447 (2005), 대한안과학회