정상 한국인 소아청소년의 망막신경섬유층 및 황반부 망막신경절세포층 두께
Retinal Nerve Fiber Layer and Macular Retinal Ganglion Cell Layer Thicknesses in Healthy Korean Children
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목적: 빛간섭단층촬영으로 측정한 정상 한국인 소아 및 청소년의 시신경유두주위 망막신경섬유층 및 황반부 망막신경절세포층 두께를 알아보고자 한다. 대상과 방법: 빛간섭단층촬영을 이용하여 5세에서 17세의 소아 및 청소년(소아군) 352명의 건강한 352안과 18세에서 75세 성인(성인군) 159명의 건강한 159안의 시신경유두주위 망막신경섬유층 및 황반부 망막신경절세포층의 두께를 측정하였다. 두 군 사이의 망막신경섬유층 및 망막신경절세포층 두께 차이를 비교하고, 나이 및 굴절값이 두 측정치에 미치는 영향을 분석하였다. 결과: 소아군과 성인군의 평균 나이는 각각 9.7 ± 3.6세, 44.7 ± 15.7세였다. 평균 망막신경섬유층및 망막신경절세포층 두께는 소아군이 103.1 ± 9.2 μm, 85.7 ± 4.6 μm였고, 성인군이 97.8 ± 8.2 μm, 82.9 ± 4.4 μm였다. 두 군의 망막신경섬유층 및 망막신경절세포층두께를 비교했을 때, 이측 사분면의 망막신경섬유층 두께(p=0.555)를 제외한 다른 모든 영역에서 소아군이 성인군보다 두꺼운 양상을보였다(p<0.05). 망막신경섬유층 및 망막신경절세포층은 근시가 심할수록, 나이가 많을수록 더 얇았다(p<0.001). 결론: 건강한 소아 및 청소년에서 빛간섭단층촬영으로 측정한 망막신경섬유층 및 망막신경절세포층 두께는 103.1 μm와 85.7 μm였고, 성인보다 더 두꺼운 분포를 보였다.
Abstract
Purpose: To measure the thicknesses of the circumpapillary retinal nerve fiber layer (RNFL) and macular retinal ganglion cell-inner plexiform layer (GCIPL) by optical coherence tomography (OCT) in healthy Korean children and adolescents. Methods: Circumpapillary RNFL and macular GCIPL thicknesses were measured by OCT in 352 healthy eyes of 352 children and adolescents (child-adolescent group) aged 5–17 years and in 159 healthy eyes of 159 adults (adult group) aged 18-75 years. The difference in RNFL and GCIPL thicknesses between the groups and the effects of age and refractive errors on the measurements were evaluated. Results: The mean age of the children and adults were 9.7 ± 3.6 and 44.7 ± 15.7 years, respectively. The mean of the average RNFL and GCIPL thicknesses were 103.1 ± 9.2 and 85.7 ± 4.6 μm, respectively, in the children group and 97.8 ± 8.2 and 82.9 ± 4.4 μm, respectively, in the adult group. The child-adolescent group had greater RNFL and GCIPL thicknesses compared to the adult group in all areas (p < 0.05) with the exception of the RNFL thickness in the temporal quadrant (p = 0.555). A thinner RNFL and thinner GCIPL were significantly associated with older age and greater myopia (p < 0.001). Conclusions: The mean RNFL and GCIPL thicknesses measured by OCT in the healthy eyes of children and adolescents were 103.1 and 85.7 μm, respectively. Children and adolescents had a thicker RNFL and GCIPL compared to adults.
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