Analysis of the Retinal Nerve Fiber Layer Thickness in Alzheimer Disease and Mild Cognitive Impairment
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Purpose: To compare the retinal nerve fiber layer (RNFL) as well as the macula volume and thickness in theeyes of age-matched healthy controls with no cognitive disabilities with those of elderly people with mild cognitiveimpairment (MCI) or Alzheimer disease (AD). We used optical coherence tomography (OCT) to determinethe effectiveness of the above quantities for early diagnosis of MCI or AD. Methods: Ninety eyes were considered in this study, split between 30 normal eyes, 30 eyes from patients withMCI, and 30eyes from patients with AD. All subjects underwent ophthalmologic and cognitive examinations,and measurements of the RNFL thickness as well as macular volume and thickness were taken for all patientsusing OCT. Results: The mean RNFL thickness upon OCT was significantly thinner in the AD group than in the MCI group(p = 0.01). The RNFL was thinner in the superior quadrant in patients with AD when compared to the healthycontrols (p = 0.03). The RNFL thicknesses in the inferior, nasal, and temporal quadrants did not differ significantlybetween the groups. Measurements in the 12 clock-hour zones revealed that zone 11 had a significantlythinner RNFL in the AD group as compared with the healthy control group (p = 0.02). In zone 2, the MCI grouphad a significantly thinner RNFL than the AD group (p = 0.03). Conclusions: Our OCT findings revealed a neuroanatomic difference in the RNFL thickness among the threegroups, i.e., the AD, MCI, and healthy control groups. This suggests that a change in average RNFL thicknesscould be a meaningful index for diagnosing early AD.
Abstract
Purpose: To compare the retinal nerve fiber layer (RNFL) as well as the macula volume and thickness in theeyes of age-matched healthy controls with no cognitive disabilities with those of elderly people with mild cognitiveimpairment (MCI) or Alzheimer disease (AD). We used optical coherence tomography (OCT) to determinethe effectiveness of the above quantities for early diagnosis of MCI or AD. Methods: Ninety eyes were considered in this study, split between 30 normal eyes, 30 eyes from patients withMCI, and 30eyes from patients with AD. All subjects underwent ophthalmologic and cognitive examinations,and measurements of the RNFL thickness as well as macular volume and thickness were taken for all patientsusing OCT. Results: The mean RNFL thickness upon OCT was significantly thinner in the AD group than in the MCI group(p = 0.01). The RNFL was thinner in the superior quadrant in patients with AD when compared to the healthycontrols (p = 0.03). The RNFL thicknesses in the inferior, nasal, and temporal quadrants did not differ significantlybetween the groups. Measurements in the 12 clock-hour zones revealed that zone 11 had a significantlythinner RNFL in the AD group as compared with the healthy control group (p = 0.02). In zone 2, the MCI grouphad a significantly thinner RNFL than the AD group (p = 0.03). Conclusions: Our OCT findings revealed a neuroanatomic difference in the RNFL thickness among the threegroups, i.e., the AD, MCI, and healthy control groups. This suggests that a change in average RNFL thicknesscould be a meaningful index for diagnosing early AD.
참고문헌 (46)
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