Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson’s Disease
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Purpose There is increasing evidence that the anterior visual pathways are involved in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). This study investigated longitudinal changes in retinal nerve fiber layer (RNFL) thickness in patients with ALS and PD with the aim of better understanding their roles as biomarkers of disease progression. Methods This study recruited 21 ALS patients, 19 age-matched PD patients, and 21 agematched healthy controls. Patient demographics and clinical scores relating to the respective diseases were documented. The RNFL thickness was measured using optical coherence tomography at baseline and after 6 months. Results At baseline, the RNFL in the superior quadrant was significantly thinner in the patients with ALS than in healthy controls (109.90±22.41 μm vs. 127.81±17.05 μm [mean±standard deviation], p=0.008). The RNFL thickness did not differ significantly between the ALS and PD patients or between the PD patients and healthy controls. At 6 months, there was further significant RNFL thinning in patients with ALS, for both the overall thickness (baseline: median=94.5 μm, range=83.0–106.0 μm; follow-up: median=93.5 μm, range=82.5–104.5 μm, p=0.043) and the thickness in the inferior quadrant (median=126 μm, range=109.5–142.5 μm; and median= 117.5 μm, range=98.5–136.5 μm; respectively, p=0.032). However, these changes were not correlated with the ALS functional scores. In contrast, the patients with PD did not demonstrate a significant change in RNFL thickness between the two time points. Conclusions The RNFL thickness is a promising biomarker of disease progression in patients with ALS but not in those with PD, which has a slower disease progression.
Abstract
Background and Purpose There is increasing evidence that the anterior visual pathways are involved in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). This study investigated longitudinal changes in retinal nerve fiber layer (RNFL) thickness in patients with ALS and PD with the aim of better understanding their roles as biomarkers of disease progression. Methods This study recruited 21 ALS patients, 19 age-matched PD patients, and 21 agematched healthy controls. Patient demographics and clinical scores relating to the respective diseases were documented. The RNFL thickness was measured using optical coherence tomography at baseline and after 6 months. Results At baseline, the RNFL in the superior quadrant was significantly thinner in the patients with ALS than in healthy controls (109.90±22.41 μm vs. 127.81±17.05 μm [mean±standard deviation], p=0.008). The RNFL thickness did not differ significantly between the ALS and PD patients or between the PD patients and healthy controls. At 6 months, there was further significant RNFL thinning in patients with ALS, for both the overall thickness (baseline: median=94.5 μm, range=83.0–106.0 μm; follow-up: median=93.5 μm, range=82.5–104.5 μm, p=0.043) and the thickness in the inferior quadrant (median=126 μm, range=109.5–142.5 μm; and median= 117.5 μm, range=98.5–136.5 μm; respectively, p=0.032). However, these changes were not correlated with the ALS functional scores. In contrast, the patients with PD did not demonstrate a significant change in RNFL thickness between the two time points. Conclusions The RNFL thickness is a promising biomarker of disease progression in patients with ALS but not in those with PD, which has a slower disease progression.
참고문헌 (38)
- Feldman EL, "Amyotrophic lateral sclerosis", Lancet, 400, pp.1363~1380 (2022)
- Shahrizaila N, "Amyotrophic lateral sclerosis and motor neuron syndromes in Asia", J Neurol Neurosurg Psychiatry, 87, pp.821~830 (2016)
- Balestrino R, "Parkinson disease", Eur J Neurol, 27, pp.27~42 (2020)
- Lim SY, "Brief clinical rating scales should not be overlooked", Mov Disord, 35, pp.1884~1885 (2020)
- Shojaie A, "Non-motor symptoms in amyotrophic lateral sclerosis : lessons from Parkinson’s disease", Amyotroph Lateral Scler Frontotemporal Degener, 24, pp.562~571 (2023)
- Nepal G, "Amyotrophic lateral sclerosis and retinal changes in optical coherence tomography : a systematic review and meta-analysis", Brain Behav, 12, pp.e2741~ (2022)
- Cerveró A, "Retinal changes in amyotrophic lateral sclerosis : looking at the disease through a new window", J Neurol, 268, pp.2083~2089 (2021)
- Kesler A, "Retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease", Clin Neurol Neurosurg, 113, pp.523~526 (2011)
- Mailankody P, "Retinal changes in Parkinson’s disease : a longitudinal follow-up study", Neurol India, 70, pp.1149~1153 (2022)
- Vujosevic S, "Optical coherence tomography as retinal imaging biomarker of neuroinflammation", neurodegeneration in systemic disorders in adults and children, 2023, pp.37, 203~219
- London A, "The retina as a window to the brain—from eye research to CNS disorders", Nat Rev Neurol, 9, pp.44~53 (2013)
- Roth NM, "Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis", Eur J Neurol, 20, pp.1170~1176 (2013)
- Brooks BR, "El Escorial revisited : revised criteria for the diagnosis of amyotrophic lateral sclerosis", Amyotroph Lateral Scler Other Motor Neuron Dis, 1, pp.293~299 (2000)
- de Carvalho M, "Electrodiagnostic criteria for diagnosis of ALS", Clin Neurophysiol, 119, pp.497~503 (2008)
- Marsili L, "Diagnostic criteria for Parkinson’s disease : from James Parkinson to the concept of prodromal disease", Front Neurol, 9, pp.156~ (2018)
- Lees AJ, "Parkinson’s disease", Lancet, 373, pp.2055~2066 (2009)
- Bakker LA, "Assessment of the factorial validity and reliability of the ALSFRS-R : a revision of its measurement model", J Neurol, 264, pp.1413~1420 (2017)
- Bhidayasiri R, "Movement Disorders: A Video Atlas", pp.4~5 (2012), Humana
- Goetz CG, "Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale : status and recommendations", Mov Disord, 19, pp.1020~1028 (2004)
- Armstrong RA, "Statistical guidelines for the analysis of data obtained from one or both eyes", Ophthalmic Physiol Opt, 33, pp.7~14 (2013)
- Devine MS, "Study of motor asymmetry in ALS indicates an effect of limb dominance on onset and spread of weakness, and an important role for upper motor neurons", Amyotroph Lateral Scler Frontotemporal Degener, 15, pp.481~487 (2014)
- Mukherjee N, "Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease", PLoS One, 12, pp.e0185242~ (2017)
- Volpe NJ, "Ophthalmic manifestations of amyotrophic lateral sclerosis(an American Ophthalmological Society thesis)", Trans Am Ophthalmol Soc, 113, pp.T12~ (2015)
- Rohani M, "Reduced retinal nerve fiber layer(RNFL)thickness in ALS patients : a window to disease progression", J Neurol, 265, pp.1557~1562 (2018)
- Khurana AK, "Anatomy and Physiology of Eye" (2017), CBS Publishers & Distributors
- Liu Z, "Comparison of optical coherence tomography findings and visual field changes in patients with primary open-angle glaucoma and amyotrophic lateral sclerosis", J Clin Neurosci, 48, pp.233~237 (2018)
- Wong BM, "Retinal nerve fiber layer in frontotemporal lobar degeneration and amyotrophic lateral sclerosis", Front Neurosci, 16, pp.964715~ (2022)
- Rojas P, "Changes in retinal OCT and their correlations with neurological disability in early ALS patients, a follow-up study", Brain Sci, 9, pp.337~ (2019)
- Menke RAL, "Neuroimaging endpoints in amyotrophic lateral sclerosis", Neurotherapeutics, 14, pp.11~23 (2017)
- Oxtoby NP, "Sequence of clinical and neurodegeneration events in Parkinson’s disease progression", Brain, 144, pp.975~988 (2021)
- Blasco H, "The glutamate hypothesis in ALS : pathophysiology and drug development", Curr Med Chem, 21, pp.3551~3575 (2014)
- Schrag A, "Rate of clinical progression in Parkinson’s disease. A prospective study", Mov Disord, 22, pp.938~945 (2007)
- Hobson P, "The estimated life expectancy in a community cohort of Parkinson’s disease patients with and without dementia, compared with the UK population", J Neurol Neurosurg Psychiatry, 81, pp.1093~1098 (2010)
- Miscioscia A, "Neurodegeneration in the retina of motoneuron diseases : a longitudinal study in amyotrophic lateral sclerosis and Kennedy’s disease", J Neurol, 270, pp.4478~4486 (2023)
- Cennamo G, "Correlation between retinal vascularization and disease aggressiveness in amyotrophic lateral sclerosis", Biomedicines, 10, pp.2390~ (2022)
- Abdul Aziz NA, "Natural history and clinical features of ALS in Malaysia", Amyotroph Lateral Scler Frontotemporal Degener, 22, pp.108~116 (2021)
- Rim TH, "Retinal vessel structure measurement using spectral-domain optical coherence tomography", Eye, 30, pp.111~119 (2016)
- Zhang Y, "Selective and inverse U-shaped curve alteration of the retinal nerve in amyotrophic lateral sclerosis : a potential mirror of the disease", Front Aging Neurosci, 13, pp.783431~ (2022)