Depth and Area of Retinal Nerve Fiber Layer Damage and Visual Field Correlation Analysis
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: To evaluate the relationship between the structural damage as assessed by time-domain optical coherencetomography (OCT) and functional changes in glaucoma. Methods: In total, 190 patients with normal tension glaucoma or primary open angle glaucoma were included inthis study. The thickness of retinal nerve fiber layer (RNFL) around the optic disc and the area of RNFL defectwere determined using OCT scans. The relationships between the RNFL thickness or area of the defect andvisual field (VF) indices were assessed using the Lowess function, regression analysis and partial Spearmancorrelation. The differences between these associations depending on the stage of VF damage were furtheranalyzed. Age, optic disc size, refraction, central corneal thickness and the presence of systemic diseasewere corrected for in order to exclude confounding factors. Results: A logarithmic scale of RNFL thickness showed a negative linear relationship with VF indices. The areaof the RNFL defect showed a weak correlation with the pattern of standard deviation, whereas the remnantRNFL thickness was moderately correlated with the pattern of standard deviation (partial Spearman correlationcoefficient, 0.39, -0.47, respectively; p < 0.0001). Many outliers were detected in the Lowess-plotted graphs. Multiplication of the area and the inverted RNFL thickness showed a moderately correlated logarithmic relationshipwith the VF indices (partial Spearman correlation coefficient, 0.46; 95% confidence interval, 0.34 to 0.57; p< 0.0001). In the severe stage of VF damage, correlation between the area of the RNFL defect and mean deviationwas significantly greater than in other stages (partial Spearman correlation coefficient, -0.66; p = 0.02). Conclusions: The thickness of the RNFL had a negative logarithmic correlation with the VF indices and wasmore relevant to the VF indices than the area of the RNFL defect, as measured by OCT.
Abstract
Purpose: To evaluate the relationship between the structural damage as assessed by time-domain optical coherencetomography (OCT) and functional changes in glaucoma. Methods: In total, 190 patients with normal tension glaucoma or primary open angle glaucoma were included inthis study. The thickness of retinal nerve fiber layer (RNFL) around the optic disc and the area of RNFL defectwere determined using OCT scans. The relationships between the RNFL thickness or area of the defect andvisual field (VF) indices were assessed using the Lowess function, regression analysis and partial Spearmancorrelation. The differences between these associations depending on the stage of VF damage were furtheranalyzed. Age, optic disc size, refraction, central corneal thickness and the presence of systemic diseasewere corrected for in order to exclude confounding factors. Results: A logarithmic scale of RNFL thickness showed a negative linear relationship with VF indices. The areaof the RNFL defect showed a weak correlation with the pattern of standard deviation, whereas the remnantRNFL thickness was moderately correlated with the pattern of standard deviation (partial Spearman correlationcoefficient, 0.39, -0.47, respectively; p < 0.0001). Many outliers were detected in the Lowess-plotted graphs. Multiplication of the area and the inverted RNFL thickness showed a moderately correlated logarithmic relationshipwith the VF indices (partial Spearman correlation coefficient, 0.46; 95% confidence interval, 0.34 to 0.57; p< 0.0001). In the severe stage of VF damage, correlation between the area of the RNFL defect and mean deviationwas significantly greater than in other stages (partial Spearman correlation coefficient, -0.66; p = 0.02). Conclusions: The thickness of the RNFL had a negative logarithmic correlation with the VF indices and wasmore relevant to the VF indices than the area of the RNFL defect, as measured by OCT.
참고문헌 (16)
- Hood DC, "A framework for comparing structural and functional measures of glaucomatous damage", Prog Retin Eye Res, 26, pp.688~710 (2007)
- Leung CK, "Analysis of retinal nerve fiber layer and optic nerve head in glaucoma with different reference plane offsets, using optical coherence tomography", Invest Ophthalmol Vis Sci, 46, pp.891~899 (2005)
- Leung CK, "Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, II: structure", function regression analysis in glaucoma, 2005, pp.46, 3702~3711
- Garway-Heath DF, "Relationship between electrophysiological, psychophysical, and anatomical measurements in glaucoma", Invest Ophthalmol Vis Sci, 43, pp.2213~2220 (2002)
- Hodapp E, "Clinical decisions in glaucoma", pp.84~126 (1993), Mosby
- Chauhan BC, "Technique for detecting serial topographic changes in the optic disc and peripapillary retina using scanning laser tomography", Invest Ophthalmol Vis Sci, 41, pp.775~782 (2000)
- Harwerth RS, "Ganglion cell losses underlying visual field defects from experimental glaucoma", Invest Ophthalmol Vis Sci, 40, pp.2242~2250 (1999)
- Bellezza AJ, "Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma", Invest Ophthalmol Vis Sci, 44, pp.623~637 (2003)
- Sommer A, "Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss", Arch Ophthalmol, 109, pp.77~83 (1991)
- Quigley HA, "An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage", Ophthalmology, 99, pp.19~28 (1992)
- Cioffi GA, "Structural-functional relationships of the optic nerve in glaucoma", J Glaucoma, 9, pp.3~4 (2000)
- Kanamori A, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography", Am J Ophthalmol, 135, pp.513~520 (2003)
- Leite MT, "Structure-function relationships using the Cirrus spectral domain optical coherence tomograph and standard automated perimetry", J Glaucoma, 21, pp.49~54 (2012)
- Lee JR, "Structure-function relationships in normal and glaucomatous eyes determined by time- and spectral-domain optical coherence tomography", Invest Ophthalmol Vis Sci, 51, pp.6424~6430 (2010)
- Sihota R, "Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage", Invest Ophthalmol Vis Sci, 47, pp.2006~2010 (2006)
- Gramer E, "Site and depth of glaucomatous visual field defects in relation to the size of the neuroretinal edge zone of the optic disk in glaucoma without hypertension, simple glaucoma, pigmentary glaucoma. A clinical study with the Octopus perimeter 201 and the optic nerve head analyzer", Klin Monbl Augenheilkd, 189, pp.190~198 (1986)