비만 여자청소년들의 뇌건강 평가를 위한 심폐체력과 혈중 BDNF, 심혈관질환 위험요인의 유용성 평가
Cardiorespiratory fitness is associated with depression symptom, blood BDNF, and cardiovascular disease risk factor in female obese adolescents
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초록
이 연구는 여자 비만 청소년들의 신경영양성인자와 연관된 심폐체력과 우울증 증후, 혈중 BDNF (brain-derived neurotrophic factor), 심혈관질환 위험요인과의 관계를 밝혀 비만 여자청소년들의 뇌 건강 예방 및 치료를 위한 변인들이 가지는 의미를 연구하는데 목적이 있다. 여자 중학생 19명(연령 15.0±0.82 세, BMI 30.66±1.88 kg/m2)이 연구에 참가하였다. 심폐체력과 우울징후 (r=-0.57, p<0/05), 혈중 콜레스테롤 (r=-0.54, p<0.05), 중성지방 (r=-0.47, p<0.05), 저밀도 지단백 콜레스테롤(r=-0.72, p<0.05), 글루코스 (r=-0.65, p<0.05)는 유의한 역상관을 보여주었고, 심폐체력과 혈중 안정 시 BDNF(r=-0.49, p<0.05)와 고밀도 지단백 콜레스테롤 (r=0.59, p<0.05)은 유의한 정상관을 보여주었다. 심폐체력 1ml/kg/min의 증가는 안정 시 혈중 BDNF 0.49ng/ml를 유의하게 증가시켰으며, 심폐체력 1ml/kg/min의 증가는 우울징후 점수 0.47을 유의하게 감소시키는 것으로 나타났다. 심폐체력과 심혈관 질환 위험요인 관련성에 대한 보다 심층적인 연구가 필요하며, 혈중 BDNF 뿐 아니라 혈소판, 근육에 내재된 BDNF 수준도 같이 고려하는 연구가 필요한 것으로 보여 진다.
Abstract
The purpose of this study was to examine the relationship in cardiorespiratory fitness, depression symptoms, blood BDNF (brain-derived neurotrophic factor), and cardiovascular disease in female obese adolescents. Forty-eight female adolescents were participated in this study (age 15.0±0.82 yrs, BMI 30.66±1.88 kg/m2). Cardiorespiratory fitness was negatively associated with depression symptoms(r=-0.57, p<0/05), blood cholesterol(r=-0.54, p<0.05), triglyceride(r=-0.47, p<0.05), low density lipoprotein(r=-0.72, p<0.05), and glucose(r=-0.65, p<0.05), respectively. Cardiorespiratory fitness was positively associated with resting blood BDNF(r=-0.49, p<0.05) and high density lipoprotein(r=0.59, p<0.05). Regression data showed that an increase by 1ml/kg/min in cardiorespiratory fitness significantly increased blood BDNF by 0.49ng/ml and significantly decreased depression symptoms by 0.47 point. Future search is needed to determine cardiorespiratory fitness and cardiovascular disease risk factor as well as considering platelet and muscle BDNF levels.
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