Gadoxetic acid 조영증강 자기공명영상에서 숙임각 변화에 따른 국소 간종양 검출능 비교
Improved Focal Liver Lesion Detection by Increasing Flip Angle During Gadoxetic Acid-Enhancement in MRI
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Gadoxetic acid (GA) 조영증강 자기공명(MR) 영상에서 일반적으로 많이 이용되는 숙임각(flip angle, FA) 11°와 비교하여 FA 30°를 이용한 3분, 10분 및 15분 영상에서 국소성 간 병변 검출 차이를 알아보고자 하였다.대상 및 방법 : 3.0T MR 기기로 GA 조영증강지연기 MR영상을 시행 받은 69명의 환자를 대상으로 하였다. 대상 환자는 간세포암 23명과 전이암 12명으로 총 35명(남성 23, 여성12, 평균연령 60.4세)이었다. GA 주입 후 3분, 10분, 15분의 영상에서 각각 FA 11˚와 30˚ 영상을 획득하였다. 각각의 영상에서 정량적평가와 정성적평가를 한 뒤 독립표본 T검정을 이용하여 통계적 분석을 하였다.정량적 평가와 정성적 평가 모두 조영제 주입 후 3분과 10분 영상에서 FA 30° 영상이 FA 11° 영상보다 약간 우수하였으나 통계적 유의성은 없었다. 그러나 15분 영상에서는 FA 30° 영상이 FA 11° 영상보다 통계적으로 유의하게 우수하였다(p<0.05). GA 조영증강 후 15분 MR영상에서 FA 30° 영상은 기존의 FA 11° 영상보다 간 병변을 민감하게 검출해낼 수 있다.
Abstract
To study the differences of focal liver lesion image detection at 3 minute, 10 minute and 15 minute time points on gadoxetic acid (GA)’s enhanced MR imaging with a flip angle (FA) of 30° compared with a 11°.The subjects were 69 patients evaluated with GA enhanced MR imaging with 3.0T MR scanner. The pa-tients are total 35(23 men and 7 women at the mean age of 60.4 years), hepatocellular carcinoma(23) and metastsis(12) except for normal, cyst and hemangioma. After GA was injected, FA 11˚ and 30˚ images were obtained at 3 minute, 10 minute and 15 minute time points respectively. After quantitative and qual-itative assessment of each image was done, statistical analysis was performed by using the independent sample T-test.From both quantitative and qualitative assessment of 3 minute and 10 minute MR images after the in-jection of GA, FA 30° images was found to be superior than FA 11°, but there were no statistical significance. However, at 15 minute time point, Statistically significant FA 30° image(p<0.05) was better than FA 11° therefore, the FA 30° improves the focal liver lesion detection. FA 30° of MR image can de-tect liver lesion more sensitively than the existing FA11° image after GA contrast enhancement at 15 mi-nute time point.
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