본문 바로가기
KERD
논문KCI 등재

Usefulness of Gadobenate Dimeglumine - Enhanced Hepatobiliary Phase MR Imaging on Predicting Histological Grade of Hepatocellular Carcinoma

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류방사선과학

초록

Purpose : To assess the usefulness of gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging for evaluation of histological characteristics of hepatocellular carcinoma (HCC). Materials and Methods : 57 HCCs histopathologically proved by surgery in 51 patients were retrospectively evaluated. All patients underwent gadobenate dimeglumine-enhanced MR imaging prior to surgery. The signal-to-noise ratio (SNR) of lesion and liver, and the liver-to-lesion contrast-to-noise ratio (CNR) for both pre- and postcontrast hepatobiliary phase were measured and contrast enhancement ratio (CER) of lesion and liver were calculated to correlate with three groups stratified by histological grades (Edmondson-Steiner classification) of the lesions. The differences between means of each group were statistically analyzed with one-way analysis of variance test. Results : The liver-to-lesion CNRs of well-differentiated HCCs (n=9) on pre- (-0.8±13.2) and postcontrast hepatobiliary phase images (13.2±30.4) were significantly (P<0.05) lower compared to those of moderately (14.2±9.4 and 39.1±15.4 on pre- and postcontrast, respectively) (n=37) and poorly differentiated HCCs (18.6±11.3 and 39.3±27.9) (n=11), respectively. There were no significant difference for CERs between three histological tumor grades. Conclusion : Gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging can help predict the histological grades of hepatocellular carcinomas preoperatively, especially differentiating well- from moderately and poorly differentiated HCCs.

Abstract

Purpose : To assess the usefulness of gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging for evaluation of histological characteristics of hepatocellular carcinoma (HCC). Materials and Methods : 57 HCCs histopathologically proved by surgery in 51 patients were retrospectively evaluated. All patients underwent gadobenate dimeglumine-enhanced MR imaging prior to surgery. The signal-to-noise ratio (SNR) of lesion and liver, and the liver-to-lesion contrast-to-noise ratio (CNR) for both pre- and postcontrast hepatobiliary phase were measured and contrast enhancement ratio (CER) of lesion and liver were calculated to correlate with three groups stratified by histological grades (Edmondson-Steiner classification) of the lesions. The differences between means of each group were statistically analyzed with one-way analysis of variance test. Results : The liver-to-lesion CNRs of well-differentiated HCCs (n=9) on pre- (-0.8±13.2) and postcontrast hepatobiliary phase images (13.2±30.4) were significantly (P<0.05) lower compared to those of moderately (14.2±9.4 and 39.1±15.4 on pre- and postcontrast, respectively) (n=37) and poorly differentiated HCCs (18.6±11.3 and 39.3±27.9) (n=11), respectively. There were no significant difference for CERs between three histological tumor grades. Conclusion : Gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging can help predict the histological grades of hepatocellular carcinomas preoperatively, especially differentiating well- from moderately and poorly differentiated HCCs.

참고문헌 (37)

  1. Ebara M, "Diagnosis of small hepatocellular carcinoma: correlation of MR imaging and tumor histologic studies", Radiology, 159, pp.371~377 (1986)
  2. Karhunen PJ, "Benign hepatic tumours and tumour like conditions in men", J Clin Pathol, 39, pp.183~188 (1986)
  3. McGahan JP, "Hepatic ablation using radiofrequency electrocautery", Invest Radiol, 25, pp.267~270 (1990)
  4. Ni Y, "The uptake of manganese dipyridoxal-diphosphate by chemically induced hepatocellular carcinoma in rats. A correlation between contrast-mediaenhanced magnetic resonance imaging, tumor differentiation, and vascularization", Invest Radiol, 28, pp.520~528 (1993)
  5. Earls JP, "Dysplastic nodules and hepatocellular carcinoma: thin-section MR imaging of explanted cirrhotic livers with pathologic correlation", Radiology, 201, pp.207~214 (1996)
  6. Murakami T, "Hepatocellular carcinoma: MR imaging with mangafodipir trisodium (Mn-DPDP)", Radiology, 200(1), pp.69~77 (1996)
  7. Kirchin MA, "Gadobenate dimeglumine (Gd-BOPTA). An overview", Invest Radiol, 33, pp.798~809 (1998)
  8. Spinazzi A, "Predictable and unpredictable adverse reactions to uroangiographic contrast media", Acad Radiol, 3(2), pp.S210~S213 (1996)
  9. Yu JS, "Hepatic cavernous hemangioma: sonographic patterns and speed of contrast enhancement on multiphase dynamic MR imaging", AJR Am J Roentgenol, 171, pp.1021~1025 (1998)
  10. Vogl TJ, "Gadobenate dimeglumine--a new contrast agent for MR imaging: preliminary evaluation in healthy volunteers", AJR Am J Roentgenol, 158, pp.887~892 (1992)
  11. Grazioli L, "MultiHance in the dynamic phase of contrast enhancement: a pictorial assessment", J Comput Assist Tomogr, 23(1), pp.S61~S64 (1999)
  12. Caudana R, "Focal malignant hepatic lesions: MR imaging enhanced with gadolinium benzyloxypropionictetra-acetate (BOPTA)--preliminary results of phase II clinical application", Radiology, 199, pp.513~520 (1996)
  13. Manfredi R, "Delayed MR imaging of hepatocellular carcinoma enhanced by gadobenate dimeglumine (Gd-BOPTA)", J Magn Reson Imaging, 9, pp.704~710 (1999)
  14. Grazioli L, "Hepatocellular carcinoma: correlation between gadobenate dimeglumineenhanced MRI and pathologic findings", Invest Radiol, 35, pp.25~34 (2000)
  15. Spinazzi A, "Multihance clinical pharmacology: biodistribution and MR enhancement of the liver", Acad Radiol, 5(1), pp.S86~S89 (1998)
  16. Petersein J, "Focal liver lesions: evaluation of the efficacy of gadobenate dimeglumine in MR imaging--a multicenter phase III clinical study", Radiology, 215, pp.727~736 (2000)
  17. Pirovano G, "Evaluation of the accuracy of gadobenate dimeglumine-enhanced MR imaging in the detection and characterization of focal liver lesions", AJR Am J Roentgenol, 175, pp.1111~1120 (2000)
  18. Kim YK, "Gadobenate dimeglumineenhanced liver MR imaging: value of dynamic and delayed imaging for the characterization and detection of focal liver lesions", Eur Radiol, 14, pp.5~13 (2004)
  19. Peterson MS, "Hepatic malignancies: usefulness of acquisition of multiple arterial and portal venous phase images at dynamic gadolinium-enhanced MR imaging", Radiology, 201, pp.337~345 (1996)
  20. Vogl TJ, "Hepatocellular carcinoma: evaluation with dynamic and static gadobenate dimeglumine-enhanced MR imaging and histopathologic correlation", Radiology, 205, pp.721~728 (1997)
  21. Ebara M, "MR imaging of small hepatocellular carcinoma: effect of intratumoral copper content on signal intensity", Radiology, 180, pp.617~621 (1991)
  22. Kitagawa K, "Hepatocellular carcinomas with excessive copper accumulation: CT and MR findings", Radiology, 180, pp.623~628 (1991)
  23. Kadoya M, "Hepatocellular carcinoma: correlation of MR imaging and histopathologic findings", Radiology, 183, pp.819~825 (1992)
  24. Yamashita Y, "Spin-echo and dynamic gadolinium-enhanced FLASH MR imaging of hepatocellular carcinoma: correlation with histopathologic findings", J Magn Reson Imaging, 4, pp.83~90 (1994)
  25. Winter TC, 3rd, "Early advanced hepatocellular carcinoma: evaluation of CT and MR appearance with pathologic correlation", Radiology, 192, pp.379~387 (1994)
  26. Manfredi R, "Gadobenate dimeglumine (BOPTA) enhanced MR imaging: patterns of enhancement in normal liver and cirrhosis", J Magn Reson Imaging, 8, pp.862~867 (1998)
  27. Ni Y, "Prolonged positive contrast enhancement with Gd-EOBDTPA in experimental liver tumors: potential value in tissue characterization", J Magn Reson Imaging, 4, pp.355~363 (1994)
  28. Hamm B, "Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging", Radiology, 195, pp.785~792 (1995)
  29. Schuhmann-Giampieri G, "Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system", Radiology, 183, pp.59~64 (1992)
  30. van Montfoort JE, "Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1", J Pharmacol Exp Ther, 290, pp.153~157 (1999)
  31. Vogl TJ, "Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA", Radiology, 200, pp.59~67 (1996)
  32. Reimer P, "Enhancement characteristics of liver metastases, hepatocellular carcinomas, and hemangiomas with Gd-EOB-DTPA: preliminary results with dynamic MR imaging", Eur Radiol, 7, pp.275~280 (1997)
  33. Huppertz A, "Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: correlation with histopathologic findings and spiral CT--initial observations", Radiology, 234, pp.468~478 (2005)
  34. Narita M, "Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma", J Gastroenterol, 44, pp.793~798 (2009)
  35. Kitao A, "Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR imaging--correlation with molecular transporters and histopathologic features", Radiology, 256, pp.817~826 (2010)
  36. Tsuboyama T, "Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging--correlation with expression of sinusoidal and canalicular transporters and bile accumulation", Radiology, 255, pp.824~833 (2010)
  37. Kim JI, "The value of gadobenate dimeglumine-enhanced delayed phase MR imaging for characterization of hepatocellular nodules in the cirrhotic liver", Invest Radiol, 43, pp.202~210 (2008)

관련 논문AI추천

Non-hypervascular Hypointense Nodules on Hepatocyte Phase Gadoxetic Acid-Enhanced MR Images: Transformation of MR Hepatobiliary Hypointense Nodules into Hypervascular Hepatocellular CarcinomasHyeon Je Cho, Ju Won Kim, Mi Young Kim, Yun Ku Cho거트앤리버 소화기연관학회협의회 · Gut and Liver2018 · 제12권 제1호Focal Liver Lesion Detection in Gadoxeic Acid-enhanced Liver MRI : Effects of Scan Delay, Hepatic Fuction, and Magnetic Field Strength김기황, 김명진, 김화선, 박미숙, 임준석, 정용은, 정재준대한자기공명의과학회 · Investigative Magnetic Resonance Imaging2011 · 제15권 제3호Ferucarbotran-Enhanced Hepatic MRI at 3T Unit: Quantitative and Qualitative Comparison of Fast Breathhold Imaging Sequences김기황, 김주희, 유정식, 정재준, 조경은대한자기공명의과학회 · Investigative Magnetic Resonance Imaging2010 · 제14권 제1호Gadoxetic acid-enhanced magnetic resonance imaging: Hepatocellular carcinoma and mimickers박미숙, Jin-Young Choi, Khalid Suliman Aljoqiman, Myeong-Jin Kim, Yeun-Yoon Kim대한간학회 · Clinical and Molecular Hepatology2019 · 제25권 제3호Pseudoglandular Formation in Hepatocellular Carcinoma Determines Apparent Diffusion Coefficient in Diffusion-Weighted MRI김주희, 유정식, 정재준, 조은석, In Kyung Park대한자기공명의과학회 · Investigative Magnetic Resonance Imaging2018 · 제22권 제2호Comparison of Three, Motion-Resistant MR Sequences on Hepatobiliary Phase for Gadoxetic Acid (Gd-EOB-DTPA)- Enhanced MR Imaging of the Liver고명주, 고수연, 김두리, 김봉수, 김승형, 송병철, 이경렬, 이무숙, 이정섭, 최국명대한자기공명의과학회 · Investigative Magnetic Resonance Imaging2017 · 제21권 제2호

이 간행물의 다른 논문 (9건)