비 인두암 체적 조절 호형 방사선 치료의 선량 계산 격자 크기에 따른 선량 체적 지수와 방사선 생물학적 지수의 평가
Evaluation of Dose Volume and Radiobiological Indices by the Dose Calculation Grid Size in Nasopharyngeal Cancer VMAT
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
The purpose of this study was to investigate the dose-volume indices and radiobiological indices according to the change in dose calculation grid size during the planning of nasopharyngeal cancer VMAT treatment. After performing the VMAT treatment plan using the 3.0 ㎜ dose calculation grid size, dose calculation from 1.0 ㎜ to 5.0 ㎜ was performed repeatedly to obtain a dose volume histogram. The dose volume index and radiobiological index were evaluated using the obtained dose volume histogram. The smaller the dose calculation grid size, the smaller the mean dose for CTV and the larger the mean dose for PTV. For OAR of spinal cord, brain stem, lens and parotid gland, the mean dose did not show a significant difference according to the change in dose calculation grid size. The smaller the grid size, the higher the conformity of the dose distribution as the CI of the PTV increases. The CI and HI showed the best results at 3.0 ㎜. The smaller the dose calculation grid size, the higher the TCP of the PTV. The smaller the dose calculation grid size, the lower the NTCP of lens and parotid. As a result, when performing the nasopharynx cancer VMAT plan, it was found that the dose calculation grid size should be determined in consideration of dose volume index, radiobiological index, and dose calculation time. According to the results of various experiments, it was determined that it is desirable to apply a grid size of 2.0 – 3.0 ㎜.
Abstract
The purpose of this study was to investigate the dose-volume indices and radiobiological indices according to the change in dose calculation grid size during the planning of nasopharyngeal cancer VMAT treatment. After performing the VMAT treatment plan using the 3.0 ㎜ dose calculation grid size, dose calculation from 1.0 ㎜ to 5.0 ㎜ was performed repeatedly to obtain a dose volume histogram. The dose volume index and radiobiological index were evaluated using the obtained dose volume histogram. The smaller the dose calculation grid size, the smaller the mean dose for CTV and the larger the mean dose for PTV. For OAR of spinal cord, brain stem, lens and parotid gland, the mean dose did not show a significant difference according to the change in dose calculation grid size. The smaller the grid size, the higher the conformity of the dose distribution as the CI of the PTV increases. The CI and HI showed the best results at 3.0 ㎜. The smaller the dose calculation grid size, the higher the TCP of the PTV. The smaller the dose calculation grid size, the lower the NTCP of lens and parotid. As a result, when performing the nasopharynx cancer VMAT plan, it was found that the dose calculation grid size should be determined in consideration of dose volume index, radiobiological index, and dose calculation time. According to the results of various experiments, it was determined that it is desirable to apply a grid size of 2.0 – 3.0 ㎜.
참고문헌 (22)
- Van Dyk J, "Commissioning and quality assurance of treatment planning computers", Int J Radiat Oncol Biol Phys, 26, pp.261~273 (1993)
- "Commissioning and quality assurance of computerized planning systems for radiation treatment of cancer", International Atomic Energy Agency, ~ (2004)
- Masi L, "Quality assurance of volumetric modulated arc therapy : evaluation and comparison of different dosimetric systems", Med Phys, 38(2), pp.612~621 (2011)
- Ren W, "Dosimetric comparison of intensity-modulated radiotherapy and volumetric-modulated arc radiotherapy in patients with prostate cancer : A meta-analysis", J Appl Clin Med Phys, 17(6), pp.254~262 (2016)
- Quan EM, "A comprehensive comparison of IMRT and VMAT plan quality for prostate cancer treatment", Int J Radiat Oncol Biol Phys, 83(4), pp.1169~1178 (2012)
- Das IJ, "Analysis of Treatment Planning Time Among Systems and Planners for Intensity-Modulated Radiation Therapy", J Am Coll Radiol, 6, pp.514~517 (2009)
- Chung HT, "Dose Variations With Varying Calculation Grid Size in Head and Neck IMRT", Phys Med Biol, 51(19), pp.4841~4856 (2006)
- Dempsey JF, "A Fourier analysis of the dose grid resolution required for accurate IMRT fluence map optimization", Med. Phys, 32, pp.380~388 (2005)
- Srivastava SP, "The dosimetric and radiobiological impact of calculation grid size on head and neck IMRT", Pract Radiat Oncol, 7, pp.209~217 (2017)
- Srivastava SP, "The effect of slice thickness on target and organs at risk volumes, dosimetric coverage and radiobiological impact in IMRT planning", Clin Transl Oncol, 18, pp.469~479 (2016)
- Akino Y, "Evaluation of superficial dosimetry between treatment planning system and measurement for several breast cancer treatment techniques", Med Phys, 40(1), pp.011714(1)~011714(6) (2013)
- "Oncentra Master Plan physics and algorithm documentation", Nucletron, ~ (2011)
- 박소현, "Physical and Biological Pretreatment Quality Assurance of the Head and Neck Cancer Plan with the Volumetric Modulated Arc Therapy", Journal of the Korean Physical Society, 67(5), pp.946~955 (2015), 한국물리학회
- Hiram A, "A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy", Physica Medica, 23, pp.115~125 (2007)
- "Prescribing, Recording, and Reporting Photon Beam Therapy (Supplement to ICRU Report 50). International Commission on Radiation Units and Measurements (ICRU). Report 62", Journal of the ICRU, 72 (2007)
- Feuvret L, "Conformity index : A review", Int J Radiat Oncol Biol Phys, 64(2), pp.333~342 (2006)
- "Prescribing, Recording, and Reporting Photon-Beam Intensity-Modulated Radiation Therapy (IMRT)", Journal of the ICRU, 10(1) (2010)
- Emami B, "Tolerance of normal tissue to therapeutic irradiation", Int. J. Radiat. Oncol. Biol. Phys, 21, pp.109~122 (1991)
- Brenner DJ, "Dose, volume, and tumor-control predictions in radiotherapy", Int. J. Radiat. Oncol. Biol. Phys, 26, pp.171~179 (1993)
- Okunieff P, "Radiation dose-response of human tumors", Int. J. Radiat. Oncol. Biol. Phys, 32(4), pp.1227~1237 (1995)
- 김연래, "체적조절호형방사선치료 시 갠트리 회전과 다엽콜리메이터의 이동 속도에 따른 선량분포 평가", 방사선기술과학, 42(3), pp.217~222 (2019), 대한방사선과학회
- 강동진, "다이나로그 파일을 이용한 부피세기조절회전치료의 정도관리", 방사선기술과학, 39(4), pp.577~585 (2016), 대한방사선과학회[DOI]