VMAT 기법을 활용한 HA-WBRT에서 빔 배열 변화에 따른 선량학적 인자 비교: 팬텀 연구
Comparison of Dosimetric Parameters Based on Beam Arrangement Changes in HA-WBRT by Using VMAT Technique: A Phantom Study
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초록
This study aimed to evaluate the impact of changes in beam arrangement and arc counts on dosimetric factors in volumetric modulated arc therapy (VMAT) inverse radiation therapy planning for hippocampal-avoidance whole brain radiation therapy (HA-WBRT) by using the Elekta Monaco radiation therapy planning system (RTPs). For coplanar VMAT, both the arc per beam (APB) method and the beam determined arc(BDA) method, which is determined by the number of beams, were applied. For non-coplanar VMAT, the BDA method was utilized, and a total of 9 treatment plans were established by varying the arc counts. All radiation therapy plans met the radiation oncology group (RTOG) 0933 protocol standards, and 14 dosimetric factors were compared and analyzed. The results showed that the BDA-NC VMAT method demonstrated superior performance in terms of planning target volume (PTV) coverage and protection of normal organs, while APB-VMAT was advantageous in terms of hippocampal protection, monitor unit and delivery time. This study is expected to contribute to the efficient establishment of HA-WBRT plans considering the changes in beam arrangement and rotation arc numbers in Monaco RTPs.
Abstract
This study aimed to evaluate the impact of changes in beam arrangement and arc counts on dosimetric factors in volumetric modulated arc therapy (VMAT) inverse radiation therapy planning for hippocampal-avoidance whole brain radiation therapy (HA-WBRT) by using the Elekta Monaco radiation therapy planning system (RTPs). For coplanar VMAT, both the arc per beam (APB) method and the beam determined arc(BDA) method, which is determined by the number of beams, were applied. For non-coplanar VMAT, the BDA method was utilized, and a total of 9 treatment plans were established by varying the arc counts. All radiation therapy plans met the radiation oncology group (RTOG) 0933 protocol standards, and 14 dosimetric factors were compared and analyzed. The results showed that the BDA-NC VMAT method demonstrated superior performance in terms of planning target volume (PTV) coverage and protection of normal organs, while APB-VMAT was advantageous in terms of hippocampal protection, monitor unit and delivery time. This study is expected to contribute to the efficient establishment of HA-WBRT plans considering the changes in beam arrangement and rotation arc numbers in Monaco RTPs.
참고문헌 (21)
- de Ruiter MB, "Hippocampal avoidance prophylactic cranial irradiation(HA-PCI)for small cell lung cancer reduces hippocampal atrophy compared to conventional PCI", Neuro-oncology, 25(1), pp.167~176 (2023)[DOI]
- Chiang PY, "Hippocampal-sparing whole-brain radiotherapy under coplanar or noncoplanar VMAT", Medical Dosimetry, 48(3), pp.134~139 (2023)[DOI]
- Aijun J, "Dosimetric evaluation of four whole brain radiation therapy approaches with hippocampus and inner ear avoidance and simultaneous integrated boost for limited brain metastases", Radiation Oncology, 14(1), pp.1~8 (2019)[DOI]
- Alejandro P, "Dosimetric comparison of four volumetric-modulated arc therapy beam arrangements utilized for hippocampal-sparing whole-brain radiation therapy", Journal of Medical Physics, 44(1), pp.1~8 (2019)[DOI]
- Trifiletti DM, "The role of whole-brain radiation therapy in patients with cerebral metastases", Cancer, 124(10), pp.2072~2074 (2018)[DOI]
- Lee YW, "Whole brain radiation-induced cognitive impairment : pathophysiological mechanisms and therapeutic targets", Biomolecules & Therapeutics, 20(4), pp.357~370 (2012)[DOI]
- Kim SH, "Functional neuroanatomy of learning and memory", The Korean Journal of Sychopathology, 8(1), pp.22~34 (1999)
- Xue J, "A simplified non-coplanar volumetric modulated arc therapy for the whole brain radiotherapy with hippocampus avoidance", Frontiers in Oncology, 13, pp.1143564~ (2023)[DOI]
- Yuen AHL, "Volumetric modulated arc therapy(VMAT)for hippocampalavoidance whole brain radiation therapy : Planning comparison with Dual-arc and Split-arc partial-field techniques", Radiation Oncology, 15(1), pp.1~10 (2020)[DOI]
- Hogstrom KR, "Review of electron beam therapy physics", Physics in Medicine and Biology, 51(13), pp.R455~R89 (2006)[DOI]
- Brown PD, "Hippocampal avoidance during whole-brain radiotherapy plus memantine for patients with brain metastases : Phase III trial NRG oncology CC001", Journal of Clinical Oncology, 38(10), pp.1019~1029 (2020)[DOI]
- Gondi V, "Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases(RTOG 0933) : A phase II multi-institutional trial", Journal of Clinical Oncology, 32(34), pp.3810~3816 (2014)[DOI]
- Kazda T, "Why and how to spare the hippocampus during brain radiotherapy : The developing role of hippocampal avoidance in cranial radiotherapy", Radiation Oncology, 9(1), pp.1~22 (2014)[DOI]
- Grosu AL, "Whole-brain irradiation with hippocampal sparing and dose escalation on metastases : Neurocognitive testing and biological imaging(HIPPORAD)-A phase II prospective randomized multicenter trial(NOA-14, ARO 2015-3, DKTK-ROG)", BMC Cancer, 20(1), pp.1~13 (2020)[DOI]
- Nevelsky A, "Hippocampal-sparing whole-brain radiotherapy using the elekta equipment", J Appl Clin Med Phys, 14(3), pp.113~120 (2013)[DOI]
- Yuen AHL, "Hybrid split-arc partial-field volumetric modulated arc therapy : an improved beam arrangement for linear accelerator-based hippocampal-avoidance whole brain radiation therapy", Reports of Practical Oncology and Radiotherapy, 27(2), pp.352~359 (2022)[DOI]
- Kalet AM, "Dosimetric comparison of single-beam multi-arc and 2-beam multi-arc VMAT optimization in the Monaco treatment planning system", Preprint, 42(2), pp.122~125 (2017)[DOI]
- Pudsey LM, "The use of collimator angle optimization and jaw tracking for VMAT-based singleisocenter multiple-target stereotactic radiosurgery for up to six targets in the Varian Eclipse treatment planning system", J Appl Clin Med Phys, 22(9), pp.171~182 (2021)[DOI]
- Guckenberger M, "Is a single arc sufficient in volumetric-modulated arc therapy(VMAT)for complex-shaped target volumes?", Radiotherapy and Oncology, 93(2), pp.259~265 (2009)[DOI]
- Chang DS, "Therapeutic ratio", Basic Radiotherapy Physics and Biology, pp.307~312 (2021)[DOI]
- Shen J, "An efficient Volumetric Arc Therapy treatment planning approach for hippocampalavoidance whole-brain radiation therapy(HA-WBRT)", Preprint, 40(3), pp.205~209 (2015)[DOI]