Adramycin의 세포독성에 대한 Gallic Acid의 영향

Abstract

The aim of this study was to eXaIIÙne the anticancer agents dirninishable a<φia<mycin cytotoxicity which has a strong side effects in cancer theraphy. Cell viability was deterrnined by MTI assay 따ter normal cells or cancer cells were treated with adria<mycin and gallic acid (1 : 1) for 48 hours. And a1so, DPPH radical scavenging ac디띠ty was ev외uated 따ter these cells were expcsed to adria<mycin only, gallic acid only or a combination of adria<mycin 빼 gallic acid (1 : 1). The results were as follows; 1. I<Æ> of adria<mycin or a combination of adria<mycin and gallic acid (1 : 1) was 127.0 !1M, 'B[j2.7 빼 res따tirely in NIH3T3 fibroblasts. 2. I<Æ> of adria<mycin or a combination of adria<mycin and gallic acid (1 : 1) was 82.3 !1M, 66.9 빠 respectirely in hurnan skin melanoma cells. 3‘ I<Æ> of adria<mycin or a combination of adria<mycin and gallic acid (1 : 1) was 86.3 !1M, 67.4 11M respectirely in human oral epithelioid carcinoma cells. 4. The range of DPPH radic외 scavenging activity was a combination of adria<mycin and gallic acid (1 1) >gallic acid > adria<mycin.