본문 바로가기
KERD
논문KCI 등재

치과 질환 극복을 위한 줄기세포의 적용

Stem Cell Applications for Overcoming Dental Diseases

김태영|김지연|이재희|황성민|김재영|안창현|하정홍|안서영|정재광|장제희|손원주|이승재
대한구강해부학회 (The Korean Academy Of Oral Anatomy)|2024.12|대한구강해부학회지 (The Korean Journal of Oral Anatomy)|제45권 제1호|pp. 67-77|DOI 10.35607/kjoa.45.1.202412.009

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

재생분화Regeneration임상적용Clinical applicationsDental diseases치과질환치계 유래 줄기세포Dental derived stem cellsDefferentiation

초록

고령화 사회에서 치과질환은 건강 및 사회적 비용이 크게 발생할 수 있는 주요한 원인이며, 구강경조직 손상 및 손실로 인하여 저작기능을 상실하게 되면 영양 불균형 및 사회활동의 위축 등 삶의 질이 크게 저하될 수 있다. 현재 치과치료는 보존적 치료나 임플란트, 보철물 등을 이용해 손상된 기능을 복원하고 있지만, 주변 조직의 손상과 제한적인 기능 복구만 가능한 한계가 존재한다. 이러한 문제점을 보완하기 위해 생체친화적인 세포수준의 연구가 반드시 필요한데, 이를 위해 다양한 줄기세포의 분화 및 적용을 통한 연구가 진행중이다. 치계 유래 줄기세포는 구강내에서 확보할 수 있으며 다양한 조직으로 분화할 수 있어 이러한 문제점을 극복할 수 있는 기술적 잠재력이 크다. 그러나 임상적 활용에 있어 안정성과 분화 유도 기술의 한계로 인해 실질적인 적용이 매우 부족한 상황이다. 지금까지 알려진 다양한 줄기세포의 특징을 확인하고 또한 주요 치과질환인 치주염, 임플란트 주위염, 충치의 치료 및 예방을 위해 줄기세포의 분화 및 이를 이용한 사례를 확인하였다. 향후 심화되는 치과 질환의 극복을 위해 줄기세포의 분화를 활용하는 임상적용 가능한 기술개발이 필요하다. 본 연구를 통해 현재의 치과질환 극복을 위한 활용가능한 줄기세포의 종류와 질환별 적용방법 및 향후 새로운 연구방향에 대해 토론하는 기회를 마련하고자 한다.

Abstract

In an aging population, dental diseases increasingly contribute to significant healthcare expenses and broader societal burdens. The loss of masticatory function due to oral hard tissue damage or degeneration can lead to severe consequences, including nutritional deficiencies and reduced social participation, significantly diminishing overall quality of life. While current dental treatments aim to restore lost function using conservative methods, implants, and prosthetics, these methods have inherent limitations regarding the extent of surrounding tissue damage and restricted functional recovery. The development of biocompatible therapies, particularly those leveraging the differentiation potential and clinical application of stem cells, is imperative to overcome these limitations. Dental-derived stem cells, easily harvested from the oral cavity, have significant potential due to their ability to differentiate into various tissue types, offering a promising approach for addressing these challenges. However, clinical applications of these cells are hindered by safety concerns and limitations in current techniques for guiding their differentiation. Therefore, further research is essential to develop clinically viable stem cell-based therapies to treat dental diseases effectively. This study aimed to review the landscape of stem cell applications in dentistry, highlighting the types of stem cells, their potential applications for specific dental conditions, and prospective research directions.

참고문헌 (67)

  1. "Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz", 2021, 931~940, 10.1007[DOI]
  2. "Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz", 2021, 879~887, 10.1007[DOI]
  3. Tonetti MS, "Dental caries and periodontal diseases in the ageing population : call to action to protect and enhance oral health and well-being as an essential component of healthy ageing-Consensus report of group 4 of the joint EFP", ORCA workshop on the boundaries between caries and periodontal diseases, 2017, pp.44(Suppl 18), S135~S144
  4. Chan AKY, "Diet, Nutrition, and Oral Health in Older Adults: A Review of the Literature", Dent J(Basel), 11(9), pp.222~ (2023)[DOI]
  5. Olaru M, "Hard Dental Tissues Regeneration-Approaches and Challenges", Materials(Basel), 14(10), pp.2558~ (2021)[DOI]
  6. Hanif A, "Complications in implant dentistry", Eur J Dent, 11(1), pp.135~140 (2017)[DOI]
  7. Mirzaei H, "Therapeutic application of multipotent stem cells", J Cell Physiol, 233(4), pp.2815~2823 (2018)[DOI]
  8. Har A, "Dental Stem Cells and Their Applications", Chin J Dent Res, 18(4), pp.207~212 (2015)[DOI]
  9. Citterio F, "Stem cells and periodontal regeneration: present and future", Plastic and Aesthetic Research, 7 (2020)[DOI]
  10. Costela-Ruiz VJ, "Different Sources of Mesenchymal Stem Cells for Tissue Regeneration: A Guide to Identifying the Most Favorable One in Orthopedics and Dentistry Applications", Int J Mol Sci, 23(11), pp.6356~ (2022)[DOI]
  11. Hosoya A, "Stem cell properties of Gli1-positive cells in the periodontal ligament", J Oral Biosci, 62(4), pp.299~305 (2020)[DOI]
  12. Park J, "Stem cell based periodontal regeneration", Korean J Oral Anatomy, 35(1), pp.51~76 (2014)[DOI]
  13. Ding, Gang, "Allogeneic periodontal ligament stem cell therapy for periodontitis in swine", Stem cells, 28(10), pp.1829~1838 (2010)[DOI]
  14. Ivanovski S, "Stem cells in the periodontal ligament", Oral Dis, 12(4), pp.358~363 (2006)[DOI]
  15. Qiu W, "Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats", J Periodontol, 95(5), pp.469~482 (2024)[DOI]
  16. Zhang, Qunzhou, "Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis", Journal of immunology, 183(12), pp.7787~7798 (2009)[DOI]
  17. Torizal FG, "Bioengineering Tooth and Periodontal Organoids from Stem and Progenitor Cells", Organoids, 3(4), pp.247~265 (2024)[DOI]
  18. Sunayana AR, "DIGITALIZED AESTHETIC REHABILITATION OF MISSING TOOTH ALONG WITH HARD AND SOFT TISSUE DEFECT BY BOTH PROSTHODONTIC AND SURGICAL APPROACH", INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH (2023)[DOI]
  19. Sloan AJ, "Dental pulp stem cells: what, where, how?", Int J Paediatr Dent, 19(1), pp.61~70 (2009)[DOI]
  20. Zhou H, "Metal-organic framework materials promote neural differentiation of dental pulp stem cells in spinal cord injury", Journal of nanobiotechnology, 21(1), pp.316~ (2023)[DOI]
  21. 김병규, "유치치수유래 줄기세포치료제의 조직재생 임상적용 위한 가능성 고찰", 대한치과의사협회지, 62(3), pp.150~163 (2024)[DOI]
  22. Han Y, "Guiding Lineage Specific Differentiation of SHED for Target Tissue", Organ Regeneration, 2021, pp.16(5), 518~534
  23. Miura M, "stem cells from human exfoliated deciduous teeth", Proc Natl Acad Sci U S A, 100(10), pp.5807~5812 (2003)[DOI]
  24. Liu Q, "Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges", Biomedicines, 11(7), pp.2047~ (2023)[DOI]
  25. Kang J, "Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy", Biomed Res Int, 2019, pp.6104738~ (2019)[DOI]
  26. Nada OA, "Stem Cells From the Apical Papilla(SCAP)as a Tool for Endogenous Tissue Regeneration", Front Bioeng Biotechnol, 6, pp.103~ (2018)[DOI]
  27. Huang GT, "Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine", J Dent Res, 88(9), pp.792~806 (2009)[DOI]
  28. Sanz JL, "Viability and Stimulation of Human Stem Cells from the Apical Papilla (hSCAPs) Induced by Silicate-Based Materials for Their Potential Use in Regenerative Endodontics: A Systematic Review", Materials (Basel), 13(4), pp.974~ (2020)[DOI]
  29. Wang Z, "Mechanisms of Embryonic Stem Cell Pluripotency Maintenance and Their Application in Livestock and Poultry Breeding", Animals(Basel), 14(12), pp.1742~ (2024)[DOI]
  30. Biswas A, "Embryonic stem cells", Stem Cells Dev, 16(2), pp.213~222 (2007)[DOI]
  31. Fu X, "DNA repair mechanisms in embryonic stem cells", Cell Mol Life Sci, 74(3), pp.487~493 (2017)[DOI]
  32. Park SJ, "Advancements in Human Embryonic Stem Cell Research : Clinical Applications and Ethical Issues", Tissue Engineering and Regenerative Medicine, 21(3), pp.379~394 (2024)[DOI]
  33. Joerger-Messerli MS, "Mesenchymal Stem Cells from Wharton's Jelly and Amniotic Fluid", Best Pract Res Clin Obstet Gynaecol, 31, pp.30~44 (2016)[DOI]
  34. Li H, "Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells", World J Stem Cells, 15(11), pp.999~1016 (2023)[DOI]
  35. Li X, "Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation", Int J Mol Med, 34(3), pp.695~704 (2014)[DOI]
  36. Klingemann H, "Mesenchymal Stem Cells-Sources and Clinical Applications", Transfus Med Hemother, 35(4), pp.272~277 (2008)[DOI]
  37. Rhie J-W, "지방줄기세포치료의 현재와 미래", 대한창상학회지, 12(2) (2016)
  38. Onizuka S, "Application of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets for Periodontal Regeneration", Int J Mol Sci, 20(11), pp.2796~ (2019)[DOI]
  39. Thalakiriyawa DS, "Advances in regenerative dentistry approaches : An update", international dental journal, 74(1), pp.25~34 (2024)[DOI]
  40. Niibe K, "The potential of enriched mesenchymal stem cells with neural crest cell phenotypes as a cell source for regenerative dentistry", Japanese Dental Science Review, 53(2), pp.25~33 (2017)[DOI]
  41. Sung HM, "Case reports of adipose-derived stem cell therapy for nasal skin necrosis after filler injection", Archives of Plastic Surgery, 39(01), pp.51~54 (2012)[DOI]
  42. Pak J, "Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells : a case series", Journal of medical case reports, 5, pp.1~8 (2011)[DOI]
  43. Bora P, "Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation", Stem Cell Res Ther, 8(1), pp.145~ (2017)[DOI]
  44. 박준혁, "한련초 추출물의 치주염 개선 효과에 관한 연구", 대한한의학회지, 39(1), pp.63~74 (2018)[DOI]
  45. 김태영, "구강조직 미세환경 특이적 구강청량제 개발의 필요성", 대한구강해부학회지, 44(1), pp.67~74 (2023)[DOI]
  46. Nirpesh Adhikari, "Disease models for the functional restoration of the periodontium based on developmental biology", 대한구강해부학회지, 40(1), pp.9~18 (2019)[DOI]
  47. Huang TH, "Unlocking the Future of Periodontal Regeneration: An Interdisciplinary Approach to Tissue Engineering and Advanced Therapeutics", Biomedicines, 12(5), pp.1090~ (2024)[DOI]
  48. Inchingolo AM, "Stem Cells: Present Understanding and Prospects for Regenerative Dentistry", J Funct Biomater, 15(10), pp.308~ (2024)[DOI]
  49. Oshima M, "Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy", PLoS One, 6(7), pp.e21531~ (2011)[DOI]
  50. Angelova Volponi A, "Adult Human Gingival Epithelial Cells as a Source for Whole-tooth Bioengineering", Journal of Dental Research, 92(4), pp.329~334 (2013)[DOI]
  51. Cai J, "Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells", Cell Regen, 2(1), pp.6~ (2013)[DOI]
  52. Galal GM, "BIOLOGICAL EVALUATION OF ADIPOSE TISSUE-DERIVED STEM CELLS ON ALVEOLAR BONE HEALING IN RATS WITH LIGATURE INDUCED PERIODONTITIS", Alexandria Dental Journal, 47(3), pp.54~62 (2022)
  53. 전재윤, "줄기세포 및 조직공학을 이용한 치조골 재생 연구에 관한 고찰", 대한치과이식학회지, 33(1), pp.1~6 (2014)
  54. 김현주, "임플란트 주위 질환 : 원인 요소 및 미생물학적접근", 대한구강악안면임플란트학회지, 22(3), pp.174~182 (2018)[DOI]
  55. Solderer A, "Regenerative surgical therapy of peri-implantitis : an umbrella review of answered", unanswered questions and future perspectives, 2020, pp.1, 614240~
  56. Matsuzaka Y, "Current Strategies and Therapeutic Applications of Mesenchymal Stem Cell-Based Drug Delivery", Pharmaceuticals(Basel), 17(6), pp.707~ (2024)[DOI]
  57. Shopova D, "Biofabrication Approaches for Peri-Implantitis Tissue Regeneration : A Focus on Bioprinting Methods", Prosthesis, 6(2), pp.372~392 (2024)[DOI]
  58. Misawa MYO, "Efficacy of stem cells on the healing of peri-implant defects : systematic review of preclinical studies", Clin Exp Dent Res, 2(1), pp.18~34 (2016)[DOI]
  59. Hendrijantini N, "Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration", Saudi Dent J, 35(2), pp.147~153 (2023)[DOI]
  60. Yoshida S, "Insight into the Role of Dental Pulp Stem Cells in Regenerative Therapy", Biology(Basel), 9(7), pp.160~ (2020)[DOI]
  61. "Acta Med Port", 2010, 663~668
  62. Park YH, "CPNE7-Induced Autophagy Restores the Physiological Function of Mature Odontoblasts", Front Cell Dev Biol, 9, pp.655498~ (2021)[DOI]
  63. Choi H, "Regulation of odontoblast differentiation by Cpne7, a dental epithelium-derived factor, via the Runx2–Nfic–Osx–Dspp pathway", Korean J Oral Anatomy, 38(1), pp.55~66 (2017)[DOI]
  64. Ebrahimi A, "Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review", Bosn J Basic Med Sci, 21(6), pp.672~701 (2021)[DOI]
  65. Al Madhoun A, "Dental Pulp Stem Cells Derived From Adult Human Third Molar Tooth: A Brief Review", Front Cell Dev Biol, 9, pp.717624~ (2021)[DOI]
  66. Varier P, "A Brief Review of In Vitro Models for Injury and Regeneration in the Peripheral Nervous System", Int J Mol Sci, 23(2), pp.816~ (2022)[DOI]
  67. Jin Y, "Application of stem cells in regeneration medicine", MedComm(2020), 4(4), pp.e291~ (2023)[DOI]

관련 논문AI추천

줄기세포 기반의 치주조직재생박재욱, 박주철대한구강해부학회 · 대한구강해부학회지2014 · 제35권 제1호구강조직유래 유도만능줄기세포 - 생체재료 복합체의 재생의료 동향김해원, 이정환, 이해형, 전수경대한치과의사협회 · 대한치과의사협회지2017 · 제55권 제12호저작 기능 상실의 문제점과 극복을 위한 연구의 필요성김재영, 김지연, 김태영, 안서영, 안창현, 이상일, 이승재, 이재희, 장제희, 정재광, 하정홍, 황성민대한구강해부학회 · 대한구강해부학회지2024 · 제45권 제1호유치치수유래 줄기세포치료제의 조직재생 임상적용 위한 가능성 고찰김병규, 김해원, 김형은, 신성진, 윤지영, 이승민, 이정환, 이해형대한치과의사협회 · 대한치과의사협회지2024 · 제62권 제3호Implications of tooth development and evolution for tooth regeneration권기정, 김기림, 김재영, 김호준, 박종훈, 손원주, 신성민, 이영균, Sanjiv Neupane대한구강해부학회 · 대한구강해부학회지2014 · 제35권 제1호Dental-derived cells for regenerative medicine: stem cells, cell reprogramming, and transdifferentiation구영, 김경화, 설양조, 이용무, 조영단대한치주과학회 · Journal of Periodontal & Implant Science2022 · 제52권 제6호

이 간행물의 다른 논문 (8건)

Wnt/β-catenin signaling in cementum formation and homeostasis조의식, 최화정pp. 1-8EAR-2 Expression in Developing Molars in Rats조세용, 김선헌, 김남량, 양동욱pp. 9-17AQP1 expression in the nerve fibers of human tooth pulp박숙경, 김윤숙, 조이슬, 김지만, 배진영, 배용철pp. 19-24Probiotics 섭취 후 구강 마이크로바이옴 변화배현숙, 조아람pp. 25-32Polydatin 처리에 의한 사람치수줄기세포(hDPSCs)의 증식과 분화촉진 효과박봉수, 강해미, 문성혁, 김인령pp. 33-38
원문 보기