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저작 기능 상실의 문제점과 극복을 위한 연구의 필요성

Challenges of Masticatory Dysfunction and Necessity for Research on Restoration

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초록

저작 기능의 상실은 단순한 영양실조, 인지 기능 저하와 같은 개인의 전신 질환에서부터 심리적 사회적인 기능 저하 그리고 경제적 비용의 증가 등 사회 전반에 걸친 복잡한 문제가 될 수 있다. 고령화 인구 및 기저질환을 가진 환자의 증가는 피할 수 없는 사회적 현상이 된 지금 저작 기능의 상실을 복구할 수 있는 다양한 연구가 실용화될 수 있어야 하지만 아직까지 치과 임플란트 식립에 크게 의존하고 있는 실정이다. 치과 임플란트 식립은 다양한 학문분야의 발전을 이용하여 현재 가장 뛰어난 저작 기능의 회복을 제공하고 있지만, 고령 또는 기저 질환이 있는 환자 그리고, 임플란트 식립 후 복합적인 합병증 등과 같은 상황에 대한 명확한 연구결과가 아직까지 부족한 단점이 있다. 이에 지금까지 저작 기능회복을 위한 다양한 분야의 과학적 노력들의 특징을 알아보고 고령화 및 기저질환 보유와 같은 상황에 적절한 저작기능 회복 연구의 방향에 대해 알아보고자 한다. 특히 다양한 줄기세포, 최신 생체재료, 그리고 조직 재생을 위한 연구에 대해 알아보고 독성 및 효용성을 확인할 수 있는 질환 실험동물모델의 정립 및 활용에 대해 자세히 알아보고자 한다. 본 연구는 향후 맞닥뜨릴 치과 분야의 새로운 문제점을 미리 확인하고 이를 대비하기 위한 새로운 방안을 모색하고자 한다.

Abstract

Tooth loss can initiate a vicious circle of systemic health problems, ranging from malnutrition to cognitive decline. Although dental implants remain the most reliable method for restoring mastication, offering efficacious solutions for functional and aesthetic rehabilitation, numerous challenges persist, particularly for older adults and patients with systemic diseases. Most studies on restoration of mastication focus on young individuals with single-disease conditions rather than aged patients with multiple comorbidities. This study reviewed recent research findings on regenerative dental science, focusing on experimental model systems in tissue engineering. Furthermore, we proposed new conceptual, experimental models to advance the healthcare environment and facilitate clinical applications.

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