유치치수유래 줄기세포치료제의 조직재생 임상적용 위한 가능성 고찰
Clinical potential of deciduous teeth-derived dental pulp-derived stem cell therapy for tissue regeneration
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Dental pulp stem cells are mesenchymal stem cells derived from the dental pulp tissue of permanent or deciduous teeth. Espe- cially, stem cells from human exfoliated deciduous teeth (SHED) have an enhanced capacity than adult pulp stem cells counterpart for self-renewal (proliferation) and multilineage differentiation, being able to generate dentin/pulp-like complexes, neural cells, skin cells, chondrocytes, and osteogenic cells, among others. Their accessibility from routine dental procedures and lack of ethical concerns make SHED an attractive stem cell source for regenerative therapy. This paper reviews current preclinical and clinical research on the tissue regenerative potential of SHED-based therapies. In preclinical animal models and clinical trials, SHED transplantation have shown promise for bone regeneration and repair, neural regeneration, myocardial infarction treatment, inflam- matory bowel disease, renal injury, liver fibrosis, diabetes mellitus, erectile dysfunction, skin wounds, muscle injury, and other con- ditions. Early-phase human trials further indicate the feasibility, safety, and efficacy of SHED based cell therapy for various disease introduced before. However, therapeutic effects from SHED injections vary greatly depending on cell source, delivery method, dose, and disease model or condition. Additional translational medicine studies for elucidating key therapeutic mechanisms of SHED and methodological advances in cell processing and delivery are needed to improve consistency. If the remaining challenges are addressed through rigorous research, SHED cell therapy may become versatile clinical (dental) materials for tissue repair and regeneration across a wide range of organs and disease states.
Abstract
Dental pulp stem cells are mesenchymal stem cells derived from the dental pulp tissue of permanent or deciduous teeth. Espe- cially, stem cells from human exfoliated deciduous teeth (SHED) have an enhanced capacity than adult pulp stem cells counterpart for self-renewal (proliferation) and multilineage differentiation, being able to generate dentin/pulp-like complexes, neural cells, skin cells, chondrocytes, and osteogenic cells, among others. Their accessibility from routine dental procedures and lack of ethical concerns make SHED an attractive stem cell source for regenerative therapy. This paper reviews current preclinical and clinical research on the tissue regenerative potential of SHED-based therapies. In preclinical animal models and clinical trials, SHED transplantation have shown promise for bone regeneration and repair, neural regeneration, myocardial infarction treatment, inflam- matory bowel disease, renal injury, liver fibrosis, diabetes mellitus, erectile dysfunction, skin wounds, muscle injury, and other con- ditions. Early-phase human trials further indicate the feasibility, safety, and efficacy of SHED based cell therapy for various disease introduced before. However, therapeutic effects from SHED injections vary greatly depending on cell source, delivery method, dose, and disease model or condition. Additional translational medicine studies for elucidating key therapeutic mechanisms of SHED and methodological advances in cell processing and delivery are needed to improve consistency. If the remaining challenges are addressed through rigorous research, SHED cell therapy may become versatile clinical (dental) materials for tissue repair and regeneration across a wide range of organs and disease states.
참고문헌 (76)
- Gronthos S, "Postnatal human dental pulp stem cells (DPSCs) and", Proceedings of the National Academy of Sciences of the United States of America, 97(25), pp.13625~13630 (2000)
- Thomson JA, "Embryonic stem cell lines derived from human blastocysts", Science, 282(5391), pp.1145~1147 (1998)
- Squillaro T, "Clinical Trials With Mesenchymal Stem Cells : An Update", Cell Transplant, 25(5), pp.829~848 (2016)
- Hass R, "Different populations and sources of human mesenchymal stem cells(MSC) : A comparison of adult and neonatal tissue-derived MSC", Cell Commun Signal, 9, pp.12~ (2011)
- La Noce M, "Dental pulp stem cells : State of the art and suggestions for a true translation of research into therapy", Journal of Dentistry, 42(7), pp.761~768 (2014)
- Gronthos S, "Stem cell properties of human dental pulp stem cells", J Dent Res, 81(8), pp.531~535 (2002)
- Trounson A, "Stem Cell Therapies in Clinical Trials : Progress and Challenges", Cell Stem Cell, 17(1), pp.11~22 (2015)
- Bunnell BA, "Adipose-derived stem cells : isolation, expansion and differentiation", Methods, 45(2), pp.115~120 (2008)
- Pittenger MF, "Multilineage potential of adult human mesenchymal stem cells", Science, 284(5411), pp.143~147 (1999)
- Shahrokhi S, "Insights and hopes in umbilical cord blood stem cell transplantations", J Biomed Biotechnol, 2012, pp.572821~ (2012)
- Tae SK, "Mesenchymal stem cells for tissue engineering and regenerative medicine", Biomed Mater, 1(2), pp.63~71 (2006)
- Miura M, "SHED : stem cells from human exfoliated deciduous teeth", Proc Natl Acad Sci U S A, 100(10), pp.5807~5812 (2003)
- Cordeiro MM, "Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth", J Endod, 34(8), pp.962~969 (2008)
- Arora V, "Banking stem cells from human exfoliated deciduous teeth(SHED) : saving for the future", J Clin Pediatr Dent, 33(4), pp.289~294 (2009)
- Mahdavi-Jouibari F, "Hopes and opportunities of stem cells from human exfoliated deciduous teeth(SHED)in cartilage tissue regeneration", Front Bioeng Biotechnol, 11, pp.1021024~ (2023)
- Liu Y, "Transplantation of SHED prevents bone loss in the early phase of ovariectomyinduced osteoporosis", J Dent Res, 93(11), pp.1124~1132 (2014)
- Lee HS, "Characteristics of stem cells from human exfoliated deciduous teeth(SHED)from intact cryopreserved deciduous teeth", Cryobiology, 71(3), pp.374~383 (2015)
- Song WP, "Clinical trials using dental stem cells : 2022 update", World J Stem Cells, 15(3), pp.31~51 (2023)
- Tsutsui TW, "Dental Pulp Stem Cells : Advances to Applications", Stem Cells Cloning, 13, pp.33~42 (2020)
- 이정환, "제2의 임플란트를 기대하며(첨생법)", 치의신보. 2023.09.13, ~ (2023)
- "첨단재생의료포털"[URL]
- Shi X, "Pulp stem cells derived from human permanent and deciduous teeth : Biological characteristics and therapeutic applications", Stem Cells Transl Med, 9(4), pp.445~464 (2020)
- Vu HT, "The Potential Application of Human Gingival Fibroblast-Conditioned Media in Pulp Regeneration : An In Vitro Study", Cells, 11(21) (2022)
- Petrenko Y, "A Comparative Analysis of Multipotent Mesenchymal Stromal Cells derived from Different Sources, with a Focus on Neuroregenerative Potential", Sci Rep, 10(1), pp.4290~ (2020)
- Zweigerdt R, "Scalable expansion of human pluripotent stem cells in suspension culture", Nat Protoc, 6(5), pp.689~700 (2011)
- Li J, "Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord", Mol Med Rep, 18(6), pp.4969~4977 (2018)
- Naz S, "Comparative analysis of dental pulp stem cells and stem cells from human exfoliated teeth in terms of growth kinetics, immunophenotype, self-renewal and multi lineage differentiation potential for future perspective of calcified tissue regeneration", Pak J Med Sci, 38(5), pp.1228~1237 (2022)
- Wang H, "Comparative characterization of SHED and DPSCs during extended cultivation in vitro", Mol Med Rep, 17(5), pp.6551~6559 (2018)
- Li P, "Immunomodulatory properties of mesenchymal stem cells", dental stem cells and their therapeutic applications, 2023, pp.20(6), 558~569
- Dave JR, "Dental Tissue-Derived Mesenchymal Stem Cells : Applications in Tissue Engineering", Crit Rev Biomed Eng, 46(5), pp.429~468 (2018)
- Chin YT, "2, 3, 5, 4'-tetrahydroxystilbene-2-O-beta-D-glucosidestimulated dental pulp stem cells-derived conditioned medium enhances cell activity and anti-inflammation", J Dent Sci, 16(2), pp.586~598 (2021)
- Gao X, "Immunomodulatory Role of Stem Cells from Human Exfoliated Deciduous Teeth on Periodontal Regeneration", Tissue Eng Part A, 24(17-18), pp.1341~1353 (2018)
- Yamaza T, "Immunomodulatory properties of stem cells from human exfoliated deciduous teeth", Stem Cell Res Ther, 1(1), pp.5~ (2010)
- Vacaru AM, "Treatment with Mesenchymal Stromal Cells Overexpressing Fas-Ligand Ameliorates Acute Graft-versus-Host Disease in Mice", Int J Mol Sci, 23(1) (2022)
- Zhao Y, "Fas ligand regulates the immunomodulatory properties of dental pulp stem cells", J Dent Res, 91(10), pp.948~954 (2012)
- Dariolli R, "Porcine adipose tissue-derived mesenchymal stem cells retain their proliferative characteristics, senescence, karyotype and plasticity after long-term cryopreservation", PLoS One, 8(7), pp.e67939~ (2013)
- Al-Saqi SH, "Defined serum-and xeno-free cryopreservation of mesenchymal stem cells", Cell Tissue Bank, 16(2), pp.181~193 (2015)
- "STEM-CELLBANKER®EX GMP grade"[URL]
- Jaiswal AN, "Cryopreservation : A Review Article", Cureus, 14(11), pp.e31564~ (2022)
- Princen K, "Hydrogels with Reversible Crosslinks for Improved Localised Stem Cell Retention : A Review", Chembiochem, 24(20), pp.e202300149~ (2023)
- Rajabzadeh N, "Stem cell-based regenerative medicine", Stem Cell Investig, 6, pp.19~ (2019)
- Kwon SG, "Recent advances in stem cell therapeutics and tissue engineering strategies", Biomater Res, 22, pp.36~ (2018)
- Buitrago JO, "Silk fibroin", collagen protein hybrid cell-encapsulating hydrogels with tunable gelation and improved physical and biological properties, 2018, pp.69, 218~233
- Kurian AG, "Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics", Bioact Mater, 8, pp.267~295 (2022)
- Lee JH, "Drug", ion co-delivery multi-functional nanocarrier to regenerate infected tissue defect, 2017, pp.142, 62~76
- Lee JH, "Intracellular codelivery of Sr ion and phenamil drug through mesoporous bioglass nanocarriers synergizes BMP signaling and tissue mineralization", Acta Biomater, 60, pp.93~108 (2017)
- Mandakhbayar N, "Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic functions", Bioact Mater, 31, pp.298~311 (2024)
- Lee CS, "Materials-based nanotherapeutics for injured and diseased bone", Prog Mater Sci, 135 (2023)
- Bayaraa O, "Nanoceria-GO-intercalated multicellular spheroids revascularize and salvage critical ischemic limbs through anti-apoptotic and pro-angiogenic functions", Biomaterials, 292 (2023)
- Lee JH, "Emerging properties of hydrogels in tissue engineering", J Tissue Eng, 9, pp.2041731418768285~ (2018)
- Davaa G, "Delivery of Induced Neural Stem Cells Through Mechano-Tuned Silk-Collagen Hydrogels for the Recovery of Contused Spinal Cord in Rats", Adv Healthc Mater, 12(7), pp.e2201720~ (2023)
- Giancola R, "Cell therapy : cGMP facilities and manufacturing", Muscles Ligaments Tendons J, 2(3), pp.243~247 (2012)
- Silva M, "Generating iPSCs : translating cell reprogramming science into scalable and robust biomanufacturing strategies", Cell Stem Cell, 16(1), pp.13~17 (2015)
- Facklam AL, "Biomaterials for Personalized Cell Therapy", Adv Mater, 32(13) (2020)
- 첨단재생의료 관련 법 및 규제의 국내외 동향, "박소라", 대한의학회, ~ (2018)
- 김민우, "첨단재생의료법의 입법 동향과 시사점", 생명, 윤리와 정책, 3(2), pp.1~18 (2019)
- Knoepfler PS, "From bench to FDA to bedside: US regulatory trends for new stem cell therapies", Adv Drug Deliv Rev, 82-83, pp.192~196 (2015)
- Hara A, "New Governmental Regulatory System for Stem Cell-Based Therapies in Japan", Ther Innov Regul Sci, 48(6), pp.681~688 (2014)
- Detela G, "EU Regulatory Pathways for ATMPs : Standard, Accelerated and Adaptive Pathways to Marketing Authorisation", Mol Ther Methods Clin Dev, 13, pp.205~232 (2019)
- Qiu T, "Regenerative medicine regulatory policies : A systematic review and international comparison", Health Policy, 124(7), pp.701~713 (2020)
- "첨단재생의료 및 첨단바이오의약품 안전 및 지원에 관한 법률", ~ (2023)
- 식품의약품안전처, "「첨단재생바이오법」자주묻는 질의응답집", ~ (2022)
- 식품의약품안전처, "세포치료제 품질관리 시험항목 설정 가이드라인", ~ (2023)
- "첨단재생의료 및 첨단바이오의약품 안전 및 지원에 관한 법률", ~ (2023)
- Frey NV, "Has allogeneic stem cell cryopreservation been given the 'cold shoulder'? An analysis of the pros and cons of using frozen versus fresh stem cell products in allogeneic stem cell transplantation", Bone Marrow Transplant, 38(6), pp.399~405 (2006)
- Li C, "Allogeneic vs. autologous mesenchymal stem", stromal cells in their medication practice, 2021, pp.11(1), 187~
- Pierdomenico L, "Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp", Transplantation, 80(6), pp.836~842 (2005)
- Kadyk LC, "Enabling allogeneic therapies : CIRM-funded strategies for immune tolerance and immune evasion", Stem Cells Transl Med, 9(9), pp.959~964 (2020)
- Collart-Dutilleul PY, "Allogenic banking of dental pulp stem cells for innovative therapeutics", World J Stem Cells, 7(7), pp.1010~1021 (2015)
- Le Blanc K, "HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells", Exp Hematol, 31(10), pp.890~896 (2003)
- Ringden O, "Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease", Transplantation, 81(10), pp.1390~1397 (2006)
- Le Blanc K, "Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease : a phase II study", Lancet, 371(9624), pp.1579~1586 (2008)
- Diez JM, "Culture of human mesenchymal stem cells using a candidate pharmaceutical grade xeno-free cell culture supplement derived from industrial human plasma pools", Stem Cell Res Ther, 6(1), pp.28~ (2015)
- Pilgrim CR, "A Review of Fetal Bovine Serum in the Culture of Mesenchymal Stromal Cells and Potential Alternatives for Veterinary Medicine", Front Vet Sci, 9, pp.859025~ (2022)
- Subbiahanadar Chelladurai K, "Alternative to FBS in animal cell culture-An overview and future perspective", Heliyon, 7(8), pp.e07686~ (2021)
- 식품의약품안전처, "고위험 첨단재생의료 연구계획 승인 절차 및 방법등에 관한 규정", ~ (2023)
