인간 거대세포 바이러스 감염 진단을 위한 CMV 항원혈증 검사의 유용성 평가

Abstract

Early detection and treatment of human cytomegalovirus(CMV) infection is very important because CMV infection is major cause of morbidity and mortality after organ transplantation. CMV antigenemia assay has been reported to be very sensitive and specific for detection of CMV infection among many laboratory methods. We compared the results of CMV antigenemia(Clonab CMV kit; Biotest AG, Landsteinerstrasse，Dreiceich, Germany), CMV PCR, CMV culture and CMV IgM to evaluate their clinical usefulness. We compared 620 samples for CMV antigenemia tests, 2,272 samples for CMV culture, and 423 samples for CMV PCR tests between July 1997 and April 1998 in samsung medical center clinical microbiology For CMV test, the sensitivity of CMV culture, CMV antigenemia, and CMV PCR were 4.3%, 16.6% and 31.0%, respectively. Sixty seven patients were classified CMV antigenemia positive. The results of compared for CMV culture, CMV PCR, and CMV IgM antibody. For CMV antigenemia, the sensitivity of CMV PCR and CMV IgM antibody were 85.3%, 93.5% respectively. CMV antigenemia is thought to be useful for early diagnosis and follow- up of antiviral treatment as a quantitative and highly specific method. The sensitivity and specificity are very comparing to CMV antigenemia.