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Pyruvate 투여가 장시간 운동 시 혈중 피로물질과 지질성분에 미치는 영향

The Effects of Pyruvate Supplementation on Blood Fatigue Factors and Lipid Components during Prolonged Exercise

우진희|백일영|이하영
국민체육진흥공단 한국스포츠과학원 (Korea Institute of Sport Science)|2005.03|체육과학연구 (Korean Journal of Sport Science)|제16권 제1호|pp. 18-26

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키워드

FFAglycerolPyruvate피로물질글리세롤지질성분pyruvatefatigue factorslipid components
주제분류체육

초록

본 연구의 목적은 비훈련군을 대상으로 운동 전 pyruvate 구강투여로 운동 중 혈중 피로물질 축적과 지질성분의 차이를 투여 전과 비교하여 ergogenic aids로서 pyruvate 효능을 검증하는데 있다. 실험 대상자는 신체 건강한 10명의 남자 대학생으로 하였으며, 두 가지 실험조건(투여전(N), pyruvate 투여(P))에 참여하였고, 두 조건 모두 5mph, 5% 경사도의 트레드밀에서 90분간 운동 후 30분의 휴식기를 가졌다. 채혈은 투여 전과 후 모두 안정시, 운동 30분, 운동 90분, 회복 30분 등 총 4회 하였으며, 채혈된 혈액으로 젖산, 무기인산, FFA, 글리세롤, TG, TC, HDL-c, LDL-c을 분석하였고, 체지방도 측정하였다. Pyruvate는 운동 전 6일간 하루 6g의 정제를 구강으로 투여하였고, 결과는 ANOVA로 분석하였으며, 사후검증은 Tukey's post hoc test로 실시하였다(p<.05). 연구결과, pyruvate 투여 후 젖산과 무기인산 농도는 운동 중과 회복하는 동안 투여 전과 비교하여 낮게 나타났으며, FFA와 글리세롤 수준도 낮게 나타났다. 혈중 지질성분의 차이는 pyruvate 투여 후 HDL-c은 증가된 반면, TG, TC, LDL-c은 감소되었고 체지방도 0.82% 감소되었다. 결론적으로, pyruvate 투여는 운동하는 동안 피로물질 축적을 감소시켜줄 뿐만 아니라, 지질산화를 증가시켜주며, 더욱이 지질성분을 긍정적으로 변화시켜줌으로써 건강에 이점을 주는 것으로 나타났다. 또한, 이러한 이점들은 건강한 사람은 물론 비만자의 체지방 감소에도 영향을 줄 수 있으리라 사료된다.

Abstract

OBJECTIVE: We investigated the effect of pyruvate supplementation on blood fatigue factors, fatty acid and glycerol metabolism and on lipid components in untrained men. METHODS: 10 male collegians participated in 2 experimental conditions(normal(N), pyruvate supplementation(P)). All subjects exercised for 90 min with a 5% gradient and a 5 mph exercise load followed with a 30 min recovery after the exercise. Blood was drawn 4 times(resting, exercise 30 min, exercise 90 min, recovery 30 min). Blood samples were used to analyze lactate, phosphorous, FFA, glycerol, TG, TC, HDL-C, LDL-C, and % body fat. For P group, the subjects received a daily dose of pyruvate 6g , orally, during 6 days. The results were analyzed by analysis of variance and Tukey's post hoc test, and significance was set at P<.05. RESULTS: In our model, pyruvate supplementation decreased the concentrations of lactate and phosphorous during exercise and recovery times. The supplement protocol also decrease blood FFA and glycerol levels. In blood lipid components, pyruvate supplementation increased HDL-C and decreased TG, TC, LDL-C. The % body fat decreased by 0.82% for supplemented group. CONCLUSIONS: This study showed that pyruvate supplementation decrease fatigue factors, but not increases lipid oxidation during exercise. Moreover, pyruvate supplementation was beneficial through changing blood lipid components and even greater effects could be expected for the reducing % fat in not only obese but also healthy men.

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