Pyruvate 섭취와 유산소 운동이 비만 남성의 혈청 요인에 변화와 신체구성에 미치는 영향
The effect of pyruvate intake and aerobic exercise on the change of serum parameters and body composition in obese men
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[목적] 본 연구는 20대 비만 남성을 대상으로 10주간 pyruvate 섭취와 유산소 운동이 신체구성, 운동수행능력, 그리고 혈액변인 및 비만 관련 호르몬에 미치는 영향을 검증하여, 비만 개선에 효과적인 물질로서 pyruvate 섭취 효과 및 유산소 운동의 효과를 규명하고자 하였다. [방법] 본 연구의 대상자는 BMI 25kg/m2 이상과 체지방률 25% 이상에 해당되는 20대 비만 남성 20명을 선정하였으며, pyruvate 섭취와 유산소 운동 집단(PYA) 10명, 위약 섭취와 유산소 운동 집단(PLA) 10명으로 무선배정 하였다. pyruvate와 위약 섭취는 각각 10주간 하루 6g씩 매일 섭취하였으며, 유산소 운동은 10주간 주 3회, 하루 60분간의 트레드밀 운동을 목표심박수 50~65% 강도로 실시하였다. pyruvate 섭취 효과 및 유산소 운동의 효과를 규명하기 위하여 신체구성, 운동수행능력, Lactate, 그리고 혈액변인 및 비만 관련 호르몬을 사전과 사후 모두 동일한 방법으로 측정하였다. [결과] 본 연구에서 얻은 주요 결과는 다음과 같다. 1) 신체구성의 경우 PYA에서 체중(p< .01), BMI(p<.05), 체지방률(p<.01), 그리고 체지방량(p<.001)이 유의하게 감소하는 것으로 나타났다. 2) 운동수행능력은 V͘O2max의 경우 PYA(p<.01)와 PLA(p<.001) 모두 유의하게 증가하였으며, 또한 운동 중 거리의 경우 15분에서 PYA(p<.01)와 PLA(p<.05), 30분에서 PYA(p<.01)와 PLA(p<.05) 유의하게 증가되었으나, 45분(p<.01)부터 60(p<.05)분까지는 PYA에서만 유의하게 증가하는 것으로 나타났다. 3) Lactate의 경우 안정시 PYA(p<.001)에서 유의하게 감소하고, 운동 30분 후 PYA(p<.001)에서 유의하게 증가하였지만 45분 후에는 유의한 차이가 나타나지 않았다. 4) 혈액변인의 경우 HDL-C의 경우 PLA(p<.05)에서 유의하게 감소되는 것으로 나타났으며, Leptin의 경우 PYA(p<.001)에서 유의하게 감소되는 것으로 나타났다. [결론] 이상의 본 연구 결과를 요약하면, 동일한 유산소 운동을 실시하더라도 pyruvate를 섭취한 PYA가 비만 개선에 더욱 효과적인 것으로 나타났다.
Abstract
[Purpose] The aim of this study is to find how the pyruvate intake and aerobic exercise effect on the body composition, exercise performance ability, blood factor and obesity related hormone, and to verify the effect of pyruvate intake and aerobic exercise as an effective substance for obesity improvement. [Methods] This study selected 20 obese men in their twenties who has more BMI than 25kg/m2, and are applicable in 25% of the body fat, and randomly sampled group of 10 people for pyruvate intake and aerobic exercise (PYA), and 10 people for placebo intake and aerobic exercise (PLA). Intake of pyruvate and placebo was implemented for 10 weeks, 6g a day, and aerobic exercise, treadmill exercise in the intensity of 50~60%’s target heart rate, was conducted for 10 weeks, 3 times a week, 60 minutes a day. To demonstrate the effect of pyruvate intake and aerobic exercise, all of the body composition, exercise performance ability, Lactate, and blood factor and hormone related to obesity were measured before and after the test in the same manner. [Results] The main results from this study are as follow; 1) In the case of body composition, in PYA, weight(p<.01), BMI(p<.05), body fat percentage(p<.01), and body weight without fat(p<.001) are reduced meaningfully. 2) In the exercise performance ability increased significantly in both PYA(p<.01) and PLA(p<.001) for V͘O2max, Also, in the case of distance during the exercise, PYA(p<.01) and PLA(p<.05) increased significantly in 15 minutes and PYA(p<.01) and PLA(p<.05) 30 minutes, but only in PYA from 45 minutes(p<.01) to 60 minutes(p<.05) 3) In case of Lactate, the significant decrease in PYA during stabilization and the significant increase in PYA after 30 minutes of exercise was not seen after 45 minutes 4) In the case of blood factor, HDL-C showed a meaningful decrease in PLA(p<.05) and Leptin showed a meaningful decrease in PYA(p<.001). [Conclusions] To sum up these results, it was more effective for the group of PYA which ingested pyruvate in improving obesity, even when the same aerobic exercise is conducted.
참고문헌 (45)
- Akbarpour, M., "The effect of aerobic training on serum adiponectin and leptin levels and inflammatory markers of coronary heart disease in obese men", Biology of Sport, 30(1), pp.21~27 (2013)
- American College of Sports Medicine, "ACSM’s Resource for Guidelines for Exercise Testing and Prescription" (2010), Lippincott Williams & Wilkins
- Arroyo-Johnson, C., "Obesity epidemiology worldwide", Gastroenterology Clinics, 45(4), pp.571~579 (2016)
- Balsan, G. A., "Relationship between adiponectin, obesity and insulin resistance", Revista da Associacao Medica Brasileira, 61(1), pp.72~80 (2015)
- Banks, W. A., "Principles of strategic drug delivery to the brain(SDDB) : development of anorectic and orexigenic analogs of leptin", Physiology and Behavior, 105(1), pp.145~149 (2011)
- Billat, L. V., "Significance of the velocity at V͘O2max and time to exhaustion at this velocity", Sports Medicine, 22(2), pp.90~108 (1996)
- Bruce, R. A., "Exercising testing in adult normal subjects and cardiac patients", Annals of Noninvasive Electrocardiology, 9(3), pp.291~303 (2004)
- Cai, M., "Effect of aerobic exercise on blood lipid and glucose in obese or overweight adults : A metaanalysis of randomised controlled trials", Obesity Research and Clinical Practice, 10(5), pp.589~602 (2016)
- Cortez, M. Y., "Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zucker rats", The American Journal of Clinical Nutrition, 53(4), pp.847~853 (1991)
- Diers, A. R., "Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells : effect of monocarboxylate transporter inhibition", Biochemical Journal, 444(3), pp.561~571 (2012)
- Gladden, L. B., "Lactate metabolism : a new paradigm for the third millennium", The Journal of Physiology, 558(1), pp.5~30 (2004)
- Gong, W., "Effect of rope skipping combining calcium pyruvate on fat metabolism of female college students", Biomedical Research, 29, pp.333~336 (2018)
- Gray, L. R., "Regulation of pyruvate metabolism and human disease", Cellular and Molecular Life Sciences, 71(14), pp.2577~2604 (2014)
- Hermann, H. P., "Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure", European Journal of Heart Failure, 6(2), pp.213~218 (2004)
- Heyward, V. H., "Advanced Fitness Assessment and Exercise Prescription" (2014), Human Kinetics
- Hulver, M. W., "Plasma leptin and exercise", Sports Medicine, 33(7), pp.473~482 (2003)
- Imayama, I., "Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight", obese postmenopausal women : a randomized controlled trial, 2012, pp.72(9), 2314~2326
- Kalman, D., "The effects of pyruvate supplementation on body composition in overweight individuals", Nutrition, 15(5), pp.337~340 (1999)
- Keating, S. E., "Effect of aerobic exercise training dose on liver fat and visceral adiposity", Journal of Hepatology, 63(1), pp.174~182 (2015)
- Koh-Banerjee, P. K., "Effects of calcium pyruvate supplementation during training on body composition, exercise capacity, and metabolic responses to exercise", Nutrition, 21(3), pp.312~319 (2005)
- Koivisto, H., "Chronic pyruvate supplementation increases exploratory activity and brain energy reserves in young and middle-aged mice", Frontiers in Aging Neuroscience, 8, pp.41~ (2016)
- Ledee, D. R., "Pyruvate modifies metabolic flux and nutrient sensing during extracorporeal membrane oxygenation in an immature swine model", American Journal of Physiology-Heart and Circulatory Physiology, 309(1), pp.137~146 (2015)
- Lee, M. G., "Resting metabolic rate after endurance exercise training", Medicine and Science in Sports and Exercise, 41(7), pp.1444~1451 (2009)
- Lundsgaard, A. M., "Molecular Regulation of Fatty Acid Oxidation in Skeletal Muscle during Aerobic Exercise", Trends in Endocrinology and Metabolism, 29(1), pp.18~30 (2017)
- McMurray, R. G., "Examining variations of resting metabolic rate of adults : a public health perspective", Medicine and Science in Sports and Exercise, 46(7), pp.1352~1358 (2014)
- Milanović, Z., "Effectiveness of high-intensity interval training(HIT)and continuous endurance training for V͘O2max improvements : a systematic review and meta analysis of controlled trials", Sports Medicine, 45(10), pp.1469~1481 (2015)
- National Health Statistics, "Ministry of Health and Welfare", ~ (2015)
- Morrison, M. A., "Pyruvate ingestion for 7 days does not improve aerobic performance in well-trained individuals", Journal of Applied Physiology, 89(2), pp.549~556 (2000)
- Motamedi, P., "The Effects of Eight-Weeks Aerobic Training on Serum Leptin Levels, Anthropometric Indices and V͘O2max in Sedentary Obese Men", Journal of Ergonomics, 5(1), pp.36~42 (2017)
- Naderi, A., "Co-ingestion of nutritional ergogenic aids and high-intensity exercise performance", Sports Medicine, 46(10), pp.1407~1418 (2016)
- Nybo, L., "High-intensity training versus traditional exercise interventions for promoting health", Medicine and Science in Sports and Exercise, 42(10), pp.1951~1958 (2010)
- Olek, R. A., "Single sodium pyruvate ingestion modifies blood acid-base status and post-exercise lactate concentration in humans", Nutrients, 6(5), pp.1981~1992 (2014)
- Onakpoya, I., "Pyruvate supplementation for weight loss : a systematic review and meta-analysis of randomized clinical trials", Critical Reviews in Food Science and Nutrition, 54(1), pp.17~23 (2014)
- Park, H. K., "Physiology of leptin : Energy homeostasis, neuroendocrine function and metabolism", Metabolism Clinical and Experimental, 64(1), pp.24~34 (2015)
- Proia, P., "Lactate as a Metabolite and a Regulator in the Central Nervous System", International Journal of Molecular Sciences, 17(9), pp.1450~1470 (2016)
- Roberts, C. K., "Metabolic syndrome and insulin resistance : Underlying causes and modification by exercise training", Comprehensive Physiology, 3(1), pp.1~58 (2013)
- Saper, R. B., "Common dietary supplements for weight loss", American Family Physician, 70, pp.1731~1740 (2004)
- Schell, J. C., "A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth", Molecular Cell, 56(3), pp.400~413 (2014)
- Segura, S., "Leptin-dependent neurotoxicity via induction of apoptosis in adult rat neurogenic cells", Frontiers in Cellular Neuroscience, 9, pp.350~350 (2015)
- Spradley, B. D., "Ingesting a pre-workout supplement containing caffeine, B-vitamins, amino acids, creatine, and beta-alanine before exercise delays fatigue while improving reaction time and muscular endurance", Nutrition and Metabolism, 9(1), pp.1~9 (2012)
- Stanko, R. T., "Plasma lipid concentrations in hyperlipidemic patients consuming a high-fat diet supplemented with pyruvate for 6 wk", The American Journal of Clinical Nutrition, 56(5), pp.950~954 (1992)
- Swift, D. L., "The role of exercise and physical activity in weight loss and maintenance", Progress in Cardiovascular Diseases, 56(4), pp.441~447 (2014)
- Wauman, J., "The Leptin Receptor Complex : Heavier Than Expected", Frontiers in Endocrinology, 8, pp.30~ (2017)
- Wu, L. S., "Response of insulin resistance indicators to aerobic exercise at different intensities in obese college students", World Academy of Science, Engineering and Technology, International Journal of Sport and Health Sciences, 11(5), pp.514~ (2017)
- Zhang, Y., "Positional cloning of the mouse obese gene and its human homologue", Nature, 372(6505), pp.425~ (1994)