활성산소종(Reactive Oxygen Species)으로 유도된 인간진피섬유아세포손상에 대한 루틴(Rutin)의 항산화 효과
The Antioxidant Effect of Rutin in Human Dermal Fibroblasts Damaged by Reactive Oxygen Species
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The reason why Reactive oxygen species (ROS) generate in a cell is harmful substances from exteriorcell. In the human body, most of the free radicals disappear by creating an oxidation inhibitor. But oxidativestress is induced when ROS can not be removed by former defenser. Oxidative stress causes DNAdenaturation, destruction of the cell membrane, Hardening of the arteries and cellular senescence, directlyor indirectly. Rutin, glycosides of quercetin, is the flavonoid-based compound which is widely distributedin the plant kingdom. Rutin was shown to strengthen capillaries and capillary action contraction is used asthe main component of the circulatory disease treatment and hypertension. In this study, we demonstratedthat pretreatment of rutin protects human dermal fibroblasts (NHDFs) from the oxidative stress. Additionalbiochemical assay showed that rutin has ROS scavenging effect and furthermore, alters mRNA expressionof SOD1 and CAT in NHDFs. Our results indicate that rutin is implicated as a potential biochemical orchemopreventive agent through phenomenas from oxidative stress in NHDFs.
Abstract
The reason why Reactive oxygen species (ROS) generate in a cell is harmful substances from exteriorcell. In the human body, most of the free radicals disappear by creating an oxidation inhibitor. But oxidativestress is induced when ROS can not be removed by former defenser. Oxidative stress causes DNAdenaturation, destruction of the cell membrane, Hardening of the arteries and cellular senescence, directlyor indirectly. Rutin, glycosides of quercetin, is the flavonoid-based compound which is widely distributedin the plant kingdom. Rutin was shown to strengthen capillaries and capillary action contraction is used asthe main component of the circulatory disease treatment and hypertension. In this study, we demonstratedthat pretreatment of rutin protects human dermal fibroblasts (NHDFs) from the oxidative stress. Additionalbiochemical assay showed that rutin has ROS scavenging effect and furthermore, alters mRNA expressionof SOD1 and CAT in NHDFs. Our results indicate that rutin is implicated as a potential biochemical orchemopreventive agent through phenomenas from oxidative stress in NHDFs.
참고문헌 (26)
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