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오수유 추출물의 미용 소재로의 기능성 분석

Functional Activities of Evodia officinalis Extract as Cosmetic Materials

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This study was carried out to investigate the antioxidative, anti-inflammatory and antimicrobial activitiesof Evodia officinalis extracts for cosmetic applications. The DPPH radical scavenging activity and nitratescavenging activity of the extract (400 ug/ml) of Evodia officinalis were 91.02 and 54%, respectively. DPPH radical scavenging activity of these extracts were higher than of BHT (standard antioxidant). Theinhibition effect of the extracts on ROS production was examined in H2O2-treated HaCaT cells. ROSproduction was significantly inhibited by the extracts of Evodia officinalis (27.5%). These inhibition effectswere increased in a dose-dependent manner. Protective effect of extracts on HaCaT cells against H2O2,rotenone, and paraquat were investigated. Evodia officinalis showed protective effect against cell deathof HaCaT cell induced by H2O2, rotenone, and paraquat significantly. Anti-inflammatory effect by inhibitionof NO production was examined in RAW264.7 cell. Experimental results show that the NO generation issuppressed in a concentration-dependent manner These Evodia officinalis extracts were tested againstStaphylococcus . epidermidis , Staphylococcus aureus , Pityrosporum ovale and along with Propionibacteriumacnes , Malassezia furfur and Candida albicans which causes skin inflammation. Paper disc assay and MICtests were carried out the various concentrations of extracts. The extracts of Evodia officinalis A displayedeffective growth inhibition against S. epidermidis , P. ovale , M. furfur , with MIC value S. epidermidis (25 ㎍/㎖) P. acnes (12.5 ㎍/㎖), P. ovale (50 ㎍/㎖), M. furfur (50 ㎍/㎖). The overall results of this study indicatethat the Evodia officinalis have the possibility to develop as cosmetic sources for skin anti-oxidant, skin antiagingand treatment of skin-related diseases.

Abstract

This study was carried out to investigate the antioxidative, anti-inflammatory and antimicrobial activitiesof Evodia officinalis extracts for cosmetic applications. The DPPH radical scavenging activity and nitratescavenging activity of the extract (400 ug/ml) of Evodia officinalis were 91.02 and 54%, respectively. DPPH radical scavenging activity of these extracts were higher than of BHT (standard antioxidant). Theinhibition effect of the extracts on ROS production was examined in H2O2-treated HaCaT cells. ROSproduction was significantly inhibited by the extracts of Evodia officinalis (27.5%). These inhibition effectswere increased in a dose-dependent manner. Protective effect of extracts on HaCaT cells against H2O2,rotenone, and paraquat were investigated. Evodia officinalis showed protective effect against cell deathof HaCaT cell induced by H2O2, rotenone, and paraquat significantly. Anti-inflammatory effect by inhibitionof NO production was examined in RAW264.7 cell. Experimental results show that the NO generation issuppressed in a concentration-dependent manner These Evodia officinalis extracts were tested againstStaphylococcus . epidermidis , Staphylococcus aureus , Pityrosporum ovale and along with Propionibacteriumacnes , Malassezia furfur and Candida albicans which causes skin inflammation. Paper disc assay and MICtests were carried out the various concentrations of extracts. The extracts of Evodia officinalis A displayedeffective growth inhibition against S. epidermidis , P. ovale , M. furfur , with MIC value S. epidermidis (25 ㎍/㎖) P. acnes (12.5 ㎍/㎖), P. ovale (50 ㎍/㎖), M. furfur (50 ㎍/㎖). The overall results of this study indicatethat the Evodia officinalis have the possibility to develop as cosmetic sources for skin anti-oxidant, skin antiagingand treatment of skin-related diseases.

참고문헌 (29)

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