방사선 기술을 이용한 옻나무 수액의 피부 알러지 저감화 효과
Reduction of Skin Allergy of Rhus verniciflua Sap Utilizing Radiation Technology
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Skin contact allergy (SCA) is not life-threatening, but a large number of people havebeen suffered from the reactions caused by various kinds of chemicals and products. Thus, in thisstudy, radiation technology was employed to improve the traditional herb addition method on theSCA reduction of Rhus verniciflua sap (RVS). Rhus verniciflua has traditionally been used as anherbal medicine plant, but its urushiol derivatives are known as a major allergen for the SCA. The present study was commenced to assess the allergenicity of both gamma-irradiated and nonirradiatedRVS by using guinea-pig maximization test (GPMT) in order to probe the mechanismof an SCA. In the acute dermal irritation assays, non-irradiated RVS caused erythema, but theirradiated RVS did not provoke any erythema on the abdominal skin of the guinea pigs. From theresult of the GPMT, urushiols, the main chemical components of RVS, were identified as an extremeskin sensitizer, and the removal of urushiols by irradiation extremely reduced the erythema. These results suggest that radiation technology is a novel method to reduce SCA through the removalof urushiols of RVS.
Abstract
Skin contact allergy (SCA) is not life-threatening, but a large number of people havebeen suffered from the reactions caused by various kinds of chemicals and products. Thus, in thisstudy, radiation technology was employed to improve the traditional herb addition method on theSCA reduction of Rhus verniciflua sap (RVS). Rhus verniciflua has traditionally been used as anherbal medicine plant, but its urushiol derivatives are known as a major allergen for the SCA. The present study was commenced to assess the allergenicity of both gamma-irradiated and nonirradiatedRVS by using guinea-pig maximization test (GPMT) in order to probe the mechanismof an SCA. In the acute dermal irritation assays, non-irradiated RVS caused erythema, but theirradiated RVS did not provoke any erythema on the abdominal skin of the guinea pigs. From theresult of the GPMT, urushiols, the main chemical components of RVS, were identified as an extremeskin sensitizer, and the removal of urushiols by irradiation extremely reduced the erythema. These results suggest that radiation technology is a novel method to reduce SCA through the removalof urushiols of RVS.
참고문헌 (11)
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