전자선 조사 방법을 통한 생분해성고분자의 표면개질 특성 평가
Surface Modification of Poly(L-lactide-co-ε-caprolactone) Nanofibers by Electron-beam Irradiation
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Electrospun nanofibers prepared with synthetic biodegradable polymer have somelimitations in regulating adhesion, proliferation, and spreading of cells because of their surfacehydrophobicity and absence of cell-interaction. In this study, we functionalized the electrospunpoly(L-lactide-co-ε-caprolactone) (PLCL) nanofibers with acrylic acid (AAc) to modulate theirsurface hydrophilicity using electron-beam irradiation method and then measured grafting ratioof AAc, water contact angle, and ATR-FTIR of AAc-grafted nanofibers. A grafting ratio of AAcon the nanofibers was increased as irradiation dose and AAc concentration were increased. AAcgraftednanofibers also have higher wettability than non-modified nanofibers. In conclusion, thosesurface-modified nanofibers may be an essential candidate to regulate cell attachment in tissueengineering applications.
Abstract
Electrospun nanofibers prepared with synthetic biodegradable polymer have somelimitations in regulating adhesion, proliferation, and spreading of cells because of their surfacehydrophobicity and absence of cell-interaction. In this study, we functionalized the electrospunpoly(L-lactide-co-ε-caprolactone) (PLCL) nanofibers with acrylic acid (AAc) to modulate theirsurface hydrophilicity using electron-beam irradiation method and then measured grafting ratioof AAc, water contact angle, and ATR-FTIR of AAc-grafted nanofibers. A grafting ratio of AAcon the nanofibers was increased as irradiation dose and AAc concentration were increased. AAcgraftednanofibers also have higher wettability than non-modified nanofibers. In conclusion, thosesurface-modified nanofibers may be an essential candidate to regulate cell attachment in tissueengineering applications.
참고문헌 (8)
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