PLGA 필름 표면에 조사된 감마선이 인산칼슘의 침전에미치는 영향평가
Effect of Gamma-ray Irradiation to Calcium Phosphate Deposition on the PLGA Films
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Gamma-ray irradiation process is very useful to modify the surface of the polymericsubstrates. In this study, we prepared gamma-ray irradiated synthetic biodegradable polymerfilms, and investigated the deposition behaviors of calcium phosphate on them by immersingsimulated body fluids (SBF). The calcium phosphate was successfully coated on the PLGA filmsafter immersing in the 5× SBF. The amounts of deposited calcium phosphate on the film increasedas gamma-ray irradiation doses and immersing time increased, in which nuclear formation ofcalcium phosphate on the films may be affected or accelerated by radiation exposure. Therefore,gamma-ray irradiation dependent surface modification can be useful in bone tissue engineering.
Abstract
Gamma-ray irradiation process is very useful to modify the surface of the polymericsubstrates. In this study, we prepared gamma-ray irradiated synthetic biodegradable polymerfilms, and investigated the deposition behaviors of calcium phosphate on them by immersingsimulated body fluids (SBF). The calcium phosphate was successfully coated on the PLGA filmsafter immersing in the 5× SBF. The amounts of deposited calcium phosphate on the film increasedas gamma-ray irradiation doses and immersing time increased, in which nuclear formation ofcalcium phosphate on the films may be affected or accelerated by radiation exposure. Therefore,gamma-ray irradiation dependent surface modification can be useful in bone tissue engineering.
참고문헌 (18)
- Electron beam grafting of polymers. in Advaces in Radiation Chemistry of Polymers, "Berejka AJ", IAEA, ~, pp.IAEA TECDOC-1420 (2003)
- Douglas T, "Porous polymer", hydroxyapatite scaffolds: characterization and biocompatibility investigations, 2009, pp.20(9), 1909~1915
- Fernades S, "The Effects of Oxygen during Gamma Radiation Sterilization of Ultra-high Molecular Weight Polyethylene", pp.5~ (1997)
- Jain RA, "The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide)(PLGA)devices", Biomaterials, 21(23), pp.2475~2490 (2000)
- Jansen JA, "Evaluation of tricalciumphosphate", hydroxyapatite cement for tooth replacement : an experimental animal study, 1995, pp.6(11), 653~657
- Jayasuriya AC, "Acceleration of biomimetic mineralization to apply in bone regeneration", Biomed. Mater, 3(1), pp.015003~ (2008)
- 고범석, "스타이렌 술폰산 고분자가 그래프트된 ETFE 막의 방사선 제조 방법 및 특성 분석", 폴리머, 34(1), pp.20~24 (2010), 한국고분자학회
- Kokubo T, "How useful is SBF in predicting in vivo bone bioactivity?", Biomaterials, 27(15), pp.2907~2915 (2006)
- 이상봉, "Preparation of Alginate", Poly(N-isopropylacrylamide) Hydrogels Using Gamma-ray Irradiation Grafting, 2004, pp.12(3), 269~275[DOI]
- Lee TJ, "Apatite-coated porous poly(lactic-co-glycolic acid)microspheres as an injectable bone substitute", J. Biomater. Sci, 21(5), pp.635~645 (2010)
- Petite H, "Tissue-engineered bone regeneration", Naure Biotechnology, 18(9), pp.959~963 (2000)
- Sarkar SK, "BARC Highlights", pp.47~48 (2007), Bhabha Reserch Centre
- 신영민, "Surface Modification of Electrospun Poly(L-lactide-co-ε-caprolactone) Fibrous Meshes with a RGD Peptide for the Control of Adhesion, Proliferation and Differentiation of the Preosteoblastic Cells", Macromolecular Research, 18(5), pp.472~481 (2010), 한국고분자학회
- Shive MS, "Biodegradation and biocompatibility of PLA and PLGA microspheres", Adv. Drug Deliv. Rev, 28(1), pp.5~24 (1997)
- Shon JY, "Preparation of polymer-coated separators using an electron beam irradiation", Nucl. Instrum. Methods. Phys. Res. B, 266(23), pp.4994~5000 (2008)
- Tihan TG, "Effect of hydrophilic-hydrophobic balance on biocompatibility of poly(methyl methacrylate) (PMMA)-hydroxyapatite (HA) composites", Mater. Chem. Phys, 118(2-3), pp.265~269 (2009)
- Yang F, "Biomimetic calcium phosphate coating on electrospun poly(ε-caprolactone)scaffolds for bone tissue engineering", Chem. Eng. J, 137(1), pp.154~161 (2008)
- Yuan X, "Formation of bone-like apatite on poly(L-lactic acid)fibers by a biomimetic process", J. Biomed. Mater. Res, 57(1), pp.140~150 (2001)