아크릴산이 그라프트된 나노섬유에서의 폴리도파민 코팅
Polydopamine Coating Behaviors on the Acrylic Acid Grafted-Nanofibers
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The surface property of the materials used in tissue engineering application has beenessential to regulate cellular behaviors by directing their adhesion on the materials. To modulatesurface property of the synthetic biodegradable materials, a variety of surface modification techniqueshave used to introduced surface functional groups or bioactive molecules, recently polydopaminecoating method have been introduce as a facile modification method which can be coatedon various materials such as polymers, metals, and ceramics regardless of their surface property. However, there are no reports about the degree of polydopamine coating on the materials withdifferent hydrophilicity. In the present study, we prepared acrylic acid grafted nanofibrous meshesusing electron-beam irradiation, and then coated meshes with polydopamine. Polydopamine successfullycoated on the all meshes, both properties of acrylic acid and polydopamine were detectedon the meshes. In addition, the degree of polydopamine deposition on the materials has been alteredaccording to surface hydrophilicity, which was approximately 8-times greater than those on thenon-modified materials. In conclusion, dual effect from the acrylic acid grafting and polydopaminemay give a chance as a alternative tool in tissue engineering application.
Abstract
The surface property of the materials used in tissue engineering application has beenessential to regulate cellular behaviors by directing their adhesion on the materials. To modulatesurface property of the synthetic biodegradable materials, a variety of surface modification techniqueshave used to introduced surface functional groups or bioactive molecules, recently polydopaminecoating method have been introduce as a facile modification method which can be coatedon various materials such as polymers, metals, and ceramics regardless of their surface property. However, there are no reports about the degree of polydopamine coating on the materials withdifferent hydrophilicity. In the present study, we prepared acrylic acid grafted nanofibrous meshesusing electron-beam irradiation, and then coated meshes with polydopamine. Polydopamine successfullycoated on the all meshes, both properties of acrylic acid and polydopamine were detectedon the meshes. In addition, the degree of polydopamine deposition on the materials has been alteredaccording to surface hydrophilicity, which was approximately 8-times greater than those on thenon-modified materials. In conclusion, dual effect from the acrylic acid grafting and polydopaminemay give a chance as a alternative tool in tissue engineering application.
참고문헌 (18)
- -caprolactone)films, "Mat. Sci. Eng. C", 2007, 309~312
- De Bartolo L, "Novel membranes and surface modification able to activate specific cellular responses", Biomol. Eng, 24(1), pp.23~26 (2007)
- Grondahl L, "Polymeric grafting of acrylic acid onto poly(3-hydroxybutyrate-co-3-hydroxyvalerate) : surface functionalization for tissue engineering applications", Biomacromolecules, 6(4), pp.2197~2203 (2005)
- Jeong SI, "Manufacture of elastic biodegradable PLCL scaffolds for mechano-active vascular tissue engineering", J. Biomater. Sci. Polym. Ed, 15(5), pp.645~660 (2004)
- Jiang JH, "Surface modification of PE porous membranes based on the strong adhesion of polydopamine and covalent immobilization of heparin", J. Membrane. Sci, 364(1-2), pp.194~202 (2010)
- Kim TG, "Biomimicking extracellular matrix : cell adhesive RGD peptide modified electrospun poly(D, Llactic-co-glycolic acid)nanofiber mesh", Tissue. Eng, 12(2), pp.221~233 (2006)
- Ku SH, "General functionalization route for cell adhesion on non-wetting surfaces", Biomaterials, 31(9), pp.2535~2541 (2010)
- Lee H, "Mussel-inspired surface chemistry for multifunctional coatings", Science, 318(5849), pp.426~430 (2007)
- Ma Z, "Cartilage tissue engineering PLLA scaffold with surface immobilized collagen and basic fibroblast growth factor", Biomaterials, 26(11), pp.1253~1259 (2005)
- Naderi H, "Review paper : Critical Issues in Tissue Engineering : Biomaterials, Cell Sources, Angiogenesis, and Drug Delivery Systems", J. Biomater. Appl, 26(4), pp.383~417 (2011)
- Park GE, "Accelerated chondrocyte functions on NaOH-treated PLGA scaffolds", Biomaterials, 26(16), pp.3075~3082 (2005)
- Shin H, "Biomimetic materials for tissue engineering", Biomaterials, 24(24), pp.4353~4364 (2003)
- Shin YM, "Modulation of spreading, proliferation, and differentiation of human mesenchymal stem cells on gelatin-immobilized poly(L-lactide-co-epsilon-caprolactone)substrates", Biomacromolecules, 9(7), pp.1772~1781 (2008)
- -caprolactone)substrates for tunable cell behaviors, "Colloids Surf. B Biointerfaces", 2011, 79~87
- 신영민, "Surface Modification of Electrospun Poly(L-lactide-co-ε-caprolactone) Fibrous Meshes with a RGD Peptide for the Control of Adhesion, Proliferation and Differentiation of the Preosteoblastic Cells", Macromolecular Research, 18(5), pp.472~481 (2010), 한국고분자학회
- Tao C, "Surface modification of diamond-like carbon films with protein via polydopamine inspired coatings", Appl. Surf. Sci, 256(1), pp.294~297 (2009)
- 양희석, "세포점착성 PLLA-PAA-RGD 지지체를 이용한 연골세포 증식시 생물반응기의 효과", 조직공학과 재생의학, 5(3), pp.498~505 (2008), 한국조직공학과 재생의학회
- Zhu LP, "Surface modification of PVDF porous membranes via poly(DOPA)coating and heparin immobilization", Colloids Surf. B Biointerfaces, 69(1), pp.152~155 (2009)