감마선 조사법을 이용한 전기방사 나노/마이크로섬유 지지체의 표면 기능화
Functionalization of Electrospun Nano/Micro-fibrous Scaffolds Using Gamma-ray Irradiation
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초록
In tissue engineering application, a fibrous structure of scaffolds has been issued as analternative system to regulate cell survival and tissue regeneration, and electrospinning techniquehas been popularly used to generate fibrous meshes or sheets mimicking the structure of nativeextracellular matrix (ECM). However, recent strategy in the scaffold development is expanded toprovide the structural property as well as a biological property of native ECM, a variety of surfacemodification techniques have been used to introduce biological property. In this study, we developedbiomimetic poly(L-lactide-co-ε-caprolactone) (PLCL) nano- and micro-fibrous scaffolds as aunique platform with structural and biological properties with native ECM using electrospinningmethod and gamma-ray irradiation. Surface morphology of the scaffolds was observed by scanningelectron microscopy, and alteration of surface property was evaluated with toluidine blue O staining,water contact angle measurement and ATR-FTIR analysis.
Abstract
In tissue engineering application, a fibrous structure of scaffolds has been issued as analternative system to regulate cell survival and tissue regeneration, and electrospinning techniquehas been popularly used to generate fibrous meshes or sheets mimicking the structure of nativeextracellular matrix (ECM). However, recent strategy in the scaffold development is expanded toprovide the structural property as well as a biological property of native ECM, a variety of surfacemodification techniques have been used to introduce biological property. In this study, we developedbiomimetic poly(L-lactide-co-ε-caprolactone) (PLCL) nano- and micro-fibrous scaffolds as aunique platform with structural and biological properties with native ECM using electrospinningmethod and gamma-ray irradiation. Surface morphology of the scaffolds was observed by scanningelectron microscopy, and alteration of surface property was evaluated with toluidine blue O staining,water contact angle measurement and ATR-FTIR analysis.
참고문헌 (10)
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