방사선 가교 기술을 이용한 유효성분 방출력이 우수한하이드로겔 제조 및 특성 분석
Characterization and Preparation of the Hydrogel has Excellent Release Effect of the Active Ingredients Using a Radiation Cross-linking Technology
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Typical radiation cross-linked hydrogels has the characteristic that high water content,but low emission efficiency of active ingredients. Therefore, the hydrogel was prepared by theaddition to collagen, which is closely related to the formation of skin wrinkles in biocompatibilityand highly water-soluble carboxymethyl cellulose sodium salt (CMC) in order to preparationof hydrogels has excellent emission efficiency of active ingredients. Hydrogels were preparedby dissolving CMC and collagen each of 0.5%, 10% concentration in deionized water. Then,prepared hydrogels are performed by gamma-radiation at 1, 3, 5 kGy irradiation dose. The resultsshowed that the gel fraction of after irradiated 3 kGy hydrogel was higher than before irradiatedgelation as long as the 55.3%. The swelling rate of irradiated 3 kGy hydrogel was lower than thenon-irradiated sample. The compressive strength of 3 kGy irradiated hydrogel was the highest. The visco-elastic did not show any significant differences, even after irradiation. The CMChydrogel in this study suggested a potential use as a material for the mask pack for improvedemission efficiency of the active ingredient and anti-wrinkles.
Abstract
Typical radiation cross-linked hydrogels has the characteristic that high water content,but low emission efficiency of active ingredients. Therefore, the hydrogel was prepared by theaddition to collagen, which is closely related to the formation of skin wrinkles in biocompatibilityand highly water-soluble carboxymethyl cellulose sodium salt (CMC) in order to preparationof hydrogels has excellent emission efficiency of active ingredients. Hydrogels were preparedby dissolving CMC and collagen each of 0.5%, 10% concentration in deionized water. Then,prepared hydrogels are performed by gamma-radiation at 1, 3, 5 kGy irradiation dose. The resultsshowed that the gel fraction of after irradiated 3 kGy hydrogel was higher than before irradiatedgelation as long as the 55.3%. The swelling rate of irradiated 3 kGy hydrogel was lower than thenon-irradiated sample. The compressive strength of 3 kGy irradiated hydrogel was the highest. The visco-elastic did not show any significant differences, even after irradiation. The CMChydrogel in this study suggested a potential use as a material for the mask pack for improvedemission efficiency of the active ingredient and anti-wrinkles.
참고문헌 (21)
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