Synthesis and Biocompatibility of PVA/NaCMC Hydrogels Crosslinked by Cyclic Freezing/thawing and Subsequent Gamma-ray Irradiation
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초록
Polyvinyl alcohol/sodium carboxymethyl cellulose (PVA/NaCMC) hydrogels were prepared by physical crosslinking (cyclic freezing/thawing) and gamma (γ)-ray irradiation to evaluate the effect of NaCMC concentration (2~8 wt%) on the mechanical properties and the biocompatibility of the PVA/NaCMC hydrogels. The swelling rate of PVA/NaCMC hydrogels regardless of irradiation rose with increasing NaCMC content from 2 wt% to 8 wt%, while the gelation rate was the reverse. As the NaCMC content increased from 2 wt% to 6 wt%, the compressive strength of the hydrogels increased dramatically from 8.5 ± 2.0 kPa to 52.7 ± 2.5 kPa before irradiation and from 13.5 ± 2.9 kPa to 65.5 ± 8.7 kPa after irradiation. When 8 wt% NaCMC was added afterwards, the compressive strength decreased however. The irradiated PVA/NaCMC hydrogels containing 6 wt% NaCMC exhibited the tailored properties of the swelling rate of 118 ± 3.7%, the gelation rate of 71.4 ± 1.3%, the strength of 65.5 ± 8.7 kPa, respectively, and no cytotoxicity was observed.
Abstract
Polyvinyl alcohol/sodium carboxymethyl cellulose (PVA/NaCMC) hydrogels were prepared by physical crosslinking (cyclic freezing/thawing) and gamma (γ)-ray irradiation to evaluate the effect of NaCMC concentration (2~8 wt%) on the mechanical properties and the biocompatibility of the PVA/NaCMC hydrogels. The swelling rate of PVA/NaCMC hydrogels regardless of irradiation rose with increasing NaCMC content from 2 wt% to 8 wt%, while the gelation rate was the reverse. As the NaCMC content increased from 2 wt% to 6 wt%, the compressive strength of the hydrogels increased dramatically from 8.5 ± 2.0 kPa to 52.7 ± 2.5 kPa before irradiation and from 13.5 ± 2.9 kPa to 65.5 ± 8.7 kPa after irradiation. When 8 wt% NaCMC was added afterwards, the compressive strength decreased however. The irradiated PVA/NaCMC hydrogels containing 6 wt% NaCMC exhibited the tailored properties of the swelling rate of 118 ± 3.7%, the gelation rate of 71.4 ± 1.3%, the strength of 65.5 ± 8.7 kPa, respectively, and no cytotoxicity was observed.
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