16S rRNA 염기서열분석과 생화학적 검사로 동정한 Microbacterium oxydans 에 의한 중심정맥관 연관 균혈증 1예
Catheter-related Bacteremia due to Microbacterium oxydans Identified by 16S rRNA Sequencing Analysis and Biochemical Characteristics
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초록
Microbacterium oxydans는 환경에 널리 분포하는 coryneform의 그람 양성 막대균으로 과거에는 오염균으로 생각되었으나최근 몇 년간 사람에서의 감염보고가 증가하고 있다. Microbacterium 균종은 60여종 이상이 알려져 있으며 균종 간에16S rRNA의 염기서열의 일치도가 높고 생화학적 성상의 차이가 명확하지 않은 경우가 있어 대부분의 임상미생물 검사실에서는 균종까지 정확히 동정하기 어려운 균으로 알려져 있다. 본 증례에서 저자들은 미만성 대세포 림프종 환자에서중심정맥관 연관 균혈증을 일으킨 M. oxydans 1예를 생화학적 성상과 16S rRNA 염기서열분석을 통해 동정하였기에 문헌고찰과 함께 보고하는 바이다. [대한임상미생물학회지 2010;13:173-177]
Abstract
Microbacterium oxydans, a coryneform gram-positive bacillus, have been isolated from a wide variety of environmental sources and reported its pathogenic potential with increasing frequency in the last few years. Microbacterium comprises more than 60 species. 16S rRNA sequences in different Microbacterium species are highly conserved and the differences of biochemical characteristics between several species are unclear. As a result, identification of Microbacterium to species level has been difficult in most clinical microbiology laboratories. In this article, we report a case of catheter-related bacteremia caused by M. oxydans that was identified by 16S rRNA sequencing analysis and phenotypic characteristics in patient with diffuse large B-cell lymphoma. (Korean J Clin Microbiol 2010;13:173-177)
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