비정형성 마이코박테리아로 잘못 동정된 Tsukamurella pulmonis 균혈증 1예
A Case Report of Tsukamurella pulmonis Infection Misidentified as Atypical Mycobacteria
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초록
본 저자들은 카테터와 연관된 Tsukamurella pulmonis 균혈증을 경험하여 보고하고자 한다. Tsukamurella는 드물게 면역억제자들에게 기회감염균으로 작용하며 특히 카테터 등 생체내 인공장치는 독립적인 위험인자로 작용한다. Tsukamurella는계통발생학적으로 Nocardia, Rhodococcus, Gordonia, Streptomyces, Corenybacterium, Mycobacterium 등과 유사하여 일반적인 표현형 검사로는 동정이 어렵다. 본원의 48세 남자환자는 처음 rpoB 유전자를 이용한 PCR-RFLP에서는 Mycobacterium aubagnense로 잘못 동정되었다. 그러나 16S rRNA 염기서열 분석과 다른 Tsukamurella 종과 구별하기 위해 시행한 생화학적 검사로 T. pulmonis를 동정할 수 있었다. [대한임상미생물학회지 2010;13:93-97]
Abstract
We report a case of catheter-related bacteremia due to Tsukamurella pulmonis. T. pulmonis is a rare cause of opportunistic infection in immunosuppressed patients and in cases of indwelling foreign materials. This infection was nearly impossible to identify using conventional phenotyping methods because of its similarities to the related genera Nocardia, Rhodococcus,Gordonia, Streptomyces, Corynebacterium,and Mycobacterium. This organism was initially misidentified as Mycobacterium aubagnense through PCR-RFLP analysis. We correctly identified this organism using 16S rRNA sequencing combined with phenotyping tests. (Korean J Clin Microbiol 2010;13:93-97)
참고문헌 (18)
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