16S rRNA 염기서열분석으로 동정한 Microbacterium oleivorans에 의한 균혈증 1예
A Case of Bacteremia Due to Microbacterium oleivorans Identified by 16S rRNA Sequencing Analysis
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초록
Microbacterium 균종은 환경에 널리 분포하는 그람 양성, coryneform의 막대균이다. 주로 오염균으로 여겨졌으나 최근면역저하자 및 정상인에서 감염을 일으켰다는 보고가 증가하고 있다. Microbacterium 균종은 약 50여 종 이상이 알려져있으며 균종 간 생화학적 특징의 차이가 명확하지 않으므로 통상적인 검사 방법으로는 균종 수준까지 정확히 동정하기어려운 균으로 알려져 있다. 따라서 정확한 Microbacterium 균종 수준까지의 동정을 위해서는 16S rRNA에 대한 염기서열 분석을 시행하여 균종을 동정하는 것이 가장 좋은 방법으로 알려져 있다. 저자들은 특이 과거력 없이 건강하였던환아에서 일시적인 균혈증을 일으킨 Microbacterium oleivorans 1예를 16S rRNA 염기서열분석을 통해 동정하였고, M. oleivorans에 의한 국내 첫 감염 보고라 판단하여 문헌고찰과 함께 보고하는 바이다.
Abstract
Microbacterium oleivorans is a gram-positive, coryneform rod bacterium. The pathogenic potential of the Microbacterium species has recently been reported to be increasing. Microbacterium comprises approximately 50 species. The differences in regards to the biochemical characteristics of Microbacterium species are unclear, and is why molecular investigations (e.g., using 16S rRNA gene sequencing) are the best method to identify the species. We report a case of bacteremia that was caused by Microbacterium oleivorans in a 4-year-old boy, who had no specific medical history. This represents the first report of M. oleivorans bacteremia in Korea.
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