다발골수종 환자에서 발생한 중심정맥관 관련 Kocuria marina 균혈증 1예
A Case of Catheter-related Kocuria marina Bloodstream Infection in a Patient with Multiple Myeloma
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초록
Kocuria 균종은 그람양성구균으로 사람의 피부나 점막, 구강인두에 존재한다. 기저질환이 있거나, 정맥관을 가진 환자에서 기회감염을 일으킨다. 문헌고찰상 K. rosea, K. kristinae, K. rhizophila 균혈증은 이미 기술된 바 있으나, K. marina에 의한 균혈증은 현재까지 보고된 바 없다. 저자들은 다발골수종 환자의 혈액에서 중심정맥관 관련 균혈증의 원인균으로 K. marina를 확인하였다. VITEK II system에서는 K. variance로 동정되었으나, 16S rRNA 유전자 염기서열분석결과 K. marina로 확인되었다. Kocuria 균종에서 종 단위의 정확한 균종 동정을 위해서는 직접 염기서열 분석과 같은 분자학적 방법이 유용할 것이다.
Abstract
Kocuria species are gram-positive cocci that are commonly found on human skin, mucosa, and oropharynx. They can cause opportunistic infections in patients with underlying disease or intravenous catheterization. Although several cases of bacteremia caused by Kocuria rosea, Kocuria kristinae, and Kocuria rhizophila have been documented, K. marina has not been reported as a bloodstream pathogen. We isolated K. marina from the blood of a patient with multiple myeloma as a cause of catheter-related bacteremia. The VITEK II system (bioMerieux, Inc.) identified the isolate as K. variance. However, 16S rRNA gene sequencing analysis identified the isolate as K. marina. Accurate identification of Kocuria to the species level requires molecular methods that precisely identify these rare pathogens.
참고문헌 (16)
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