식물자원으로부터 Angiotensin converting enzyme 저해활성 탐색

Abstract

Angiotensin converting enzyme(ACE) belongs to the class of zinc protease and plays an important role in the regulation of blood pressure. In this experiment, we investigated the inhibitory activities of ninty four plant extracts on ACE. The extracts were prepared by water and refluxing with 70% and 100% methanol Among the extracts, two plant extracts such as Cassia tora, Persicaria cochinchinensis Kitagawa showed more than 60% inhibitory activities, and Foeniculum vulgare Gaertner, Scutellaria baicalensis Georgl, Caragana sinica (Buchoz) Rehder, Inula britannica var. chinensis showed 45.2~49.7% inhibitory activities. Twenty eight plant extracts such as Hemeronatum odoratum, Phellodendron amurense Decne, Inula britannica var. chinensis, Xanthium strumarium, Ploygonatum odoratum, Phellodendron amurense Rupr, Coix lachryma-jobi var. mayuen, Prunus ansu, Hibiscus mutabilis L, Trichosanthes kirilowii, Helianthus annuus, Juglans sinensis showed 30.3~39.7% Inhibitory activities. These results suggest that plant extracts which contain high ACE inhibitory activities may be useful as anti-hypertension agents and to the treatment of hypertension.