헛개나무의 Angiotensin 전환 효소 저해 및 항산화 활성

Abstract

To develop a new functional materials, angiotensin converting enzyme (ACE) inhibitory activity, antioxidant effect and total phenolic content of Hovenia dulcis Thunb. cortex were evaluated. Methanol and water extract of H. dulcis inhibited ACE by 81% and 76%, respectively, at the concentration of 4,000 ㎍ㆍ㎖-¹which were similar level with that (85%) of commercial peptide-type ACE inhibitor. Superoxide radical scavenging activity of two extracts (99.5%~99.9%) were stronger than that (69%) of ascorbic acid at the final concentration of 200 ㎍ㆍ㎖-¹. Among the solvent fractions, ether and ethylacetate fraction showed also potent scavenging activities (91% and 85%) for superoxide radical. Inhibitory activities of two extracts on oxidation of human low density lipoprotein (LDL) which were similar with that of α-tocopheol, were higher than 80% at the concentration of 50 ㎍ㆍ㎖-¹. Total phenol contents of methanol and water extracts were 7.2% and 3.6%, respectively, and that of ethylacetate showed the highest value as 60.8% among the solvent fractions. Therefore, it has been suggested that H.dulcis cortex could be a effective anti-hypertention and antioxidant resource to develope a new functional material.