약용식물의 Angiotensin converting enzyme 저해활성 탐색

Abstract

Angiotensin converting enzyme(ACE) belongs to the class of zinc protease and plays an important role in the regulation of blood pressure. In this experiment, we investigated the inhibitory activities of medicinal plant extracts on ACE. Fifty medicinal plants were selected and the extracts were prepared by refluxing with 70% methanol. Among the extracts, eleven medicinal plant extracts such as Sedum sarmentosum Bunge, Petasites japonicus(s.et z.) Max, Rubus coreanus, Morus bombycis Koidz, Acoorus calamus var. angustatus, Glycyrhixza glabra, Equisetum hyemale, Portulaca oleracea L., Prunella vulgaris var. lilacina Nakai, Sorbus commixta Hedl, Allium, thunbergii showed more than 50% inhibitory activities, and Paeonia suffruticosa Andr., Inula helenium, Acanthopanax seenticosus Harms, Dendrobium moniliforme, Juglans mandshurica, Zizyphus jujuba, Leonurus artemisia, Aster scaber Thunb, Vitex rotundifloia, Platycodon grandiflorum, Prunus persica, LIgularia fischeri showed 40~49% inhibitory activities. Therefore these extracts which contain high ACE inhibitory activities may be useful as anti-hypertension agents and to the treatment of hypertension.