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Inhibitory Effects of Artemisia capillaris Thumb.on α-Glucosidase and α-Amylase

김창현|Sung-Jin Lee
한국약용작물학회|2007.04|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제15권 제2호|pp. 128-131

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참고문헌

키워드

Artemisia capillaries Thumb.postprandial hyperglycemiamaltaseα-amylase

초록

This study was carried out to investigate inhibitory effect of extracts from Artemisia capillaris Thumb. on maltase, sucrase, α-amylase, nonspecific α-glucosidase, and postprandial hyperglycemia. Methanol extract and organic solvent (nhexane, ethyl acetate, butanol, aqueous) fractions from the medicinal herb were determined for the inhibitory activities against maltase, sucrase and α-amylase. The methanol extract from A. capillaris strongly inhibited maltase (57%) and α-glucosidase (72%) at the concentration of 100㎍/㎖. Among the four fractions (n-hexane, ethyl acetate, butanol, aqueous) examined, the butanol fraction from A. capillaris showed potent inhibitory effects on maltase (73%), sucrase (33%), and α-amylase (75%) at the concentration of 100㎍/㎖. The butanol fraction from Artemisia capillaris also exhibited significant reductions (20%) of blood glucose elevation in mice loaded with maltose. These results suggest that the extract from Artemisia capillaris can be used as a new nutraceutical for inhibition on postprandial hyperglycemia

Abstract

This study was carried out to investigate inhibitory effect of extracts from Artemisia capillaris Thumb. on maltase, sucrase, α-amylase, nonspecific α-glucosidase, and postprandial hyperglycemia. Methanol extract and organic solvent (nhexane, ethyl acetate, butanol, aqueous) fractions from the medicinal herb were determined for the inhibitory activities against maltase, sucrase and α-amylase. The methanol extract from A. capillaris strongly inhibited maltase (57%) and α-glucosidase (72%) at the concentration of 100㎍/㎖. Among the four fractions (n-hexane, ethyl acetate, butanol, aqueous) examined, the butanol fraction from A. capillaris showed potent inhibitory effects on maltase (73%), sucrase (33%), and α-amylase (75%) at the concentration of 100㎍/㎖. The butanol fraction from Artemisia capillaris also exhibited significant reductions (20%) of blood glucose elevation in mice loaded with maltose. These results suggest that the extract from Artemisia capillaris can be used as a new nutraceutical for inhibition on postprandial hyperglycemia

참고문헌 (11)

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  4. "Assay of intestinal disaccharidases. EnzymologicaBiologica et Clinica 11" (1970), 52-56.
  5. "Vasorelaxants from Chineseherbs", pp.211~213 (1991), possess immuno suppressiveproperties. Eur. J. Pharmacol. 198
  6. "The effect ofalpha-glucosidase inhibiton on intestinal disaccharidase activityin normal and diabetic mice. Metabolism 32", pp.793~799 (1983)
  7. "Drug therapy of postprandial hyperglycemia", 57, pp.19~29 (1999)
  8. "A newmethod for the determination of α-amylase. Experientia", pp.805~ (1967)
  9. "Increased disaccharidaseactivity in human diabetics. Am. J. Clin. Nutr. 28", pp.621~625 (1975)
  10. "Isolation and identification of alpha-glucosidase inhibitors from Tochucha (Eucommia ulmodes)", 61, pp.177~178 (1997)
  11. "Prevention of complications in non-insulin-dependent diabetes mellitus (NIDDM)", 50, pp.263~288 (1995)

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