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논문

한국산 자생 수목 유래 수피추출물의 종양괴사인자 억제효과

Inhibitory Effect of Extracts from Woody Plants on Tumor Necrosis Factor-α Production in Lipopolysaccharide-Stimulated RAW264.7 cells

조재열
한국약용작물학회|2007.08|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제15권 제4호|pp. 271-275

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Abstract

Naturally occurring substances are important biomedical resources with low toxicity and ethnopharmacology- based efficacy. Four out of 45 extracts (Celastrus orbiculatus, Cercis chinensis, Stephanadra incisa, and Weigela subsessilis) prepared from the bark of Korea Forest plants exhibited more than 50% of inhibition on TNF-α production in lipopolysaccharide (LPS)-activated RAW264.7 cells at 100㎍/㎖. In particular, potential inhibitory components of 4 extracts showed more than 50% inhibition seemed to be concentrated in methylene chloride (MC) fraction from C. orbiculatus, in ethyl acetate (EtOAc) fraction from C. chinensis and in hexane (Hx) fraction from S. incisa, whereas inhibitory activities of W. subssilis were broadly seen in non-polar solvent fractions such as Hx, MC and EtOAc. Therefore, our results suggest that extracts from C. orbiculatus, C. chinensis, S. incisa and W. subsessilis may be developed as a therapeutic remedy against TNF-α-mediated diseases such as rheumatoid arthritis or further fractionated to isolate active components having anti- TNF-α inhibitory activity.

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