알츠하이머 치매 환자의 혈청 항산화제 농도 감소
Decreased Plasma Antioxidants Level in Patients with Dementia of Alzheimer's Type
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초록
알츠하이머 치매는 장기간의 전구기와 임상전기를 거치 게 되며, 길게는 치매로 진단되기 20여 년 전부터 이미 환자의 뇌에서 생화학적 변화가 나타난다.35) 따라서 알츠 하이머 치매의 원인 규명과 더불어 치매의 조기 진단 및 치 료가 중요하며, 알츠하이머 치매에서 신경세포의 산화 손 상 가설을 구체화 시키는 연구는 이러한 기대를 앞당기는 중요한 계기가 될 것이다. 향후, 본 논문에서 언급한 중첩 요인들의 영향을 최소화 할 수 있도록, 피험자를 무작위 선 정한 장기간의 전향적 코호트 연구가 진행되어져야 할 것 으로 생각한다.
Abstract
Objectives：Previous studies have suggested that oxidative injuries to the neuron may have important role in the pathophysiologic mechanisms of dementia of Alzheimer’s type. In the present study, we evaluate the plasma levels of albumin, total bilirubin, and uric acid in the patients with dementia of Alzheimer’s type, and compare to those of the healthy controls. Methods：The plasma albumin, bilirubin, and uric acid levels were measured by standard methods in 102 patients with dementia of Alzheimer’s type (male 42, female 60) and 99 healthy controls (male 47, felmale 52). The Korean version of Mini Mental Status Examination (MMSE-K) was used to evaluate the cognitive functions of patients with dementia of Alzheimer’s type. Results：The plasma albumin (F=36.179, p<0.001), bilirubin (F=101.508, p<0.001), uric acid (F=12.688, p<0.001) levels in the patients with dementia of Alzheimer’s type were significantly lower than those of the healthy controls. The scores of MMSE-K were positively correlated with the plasma albumin level in the patients with dementia of Alzheimer’s type after adjusted for covariates such as age, gender, and body mass index (p=0.017). Conclusion：This study supported that oxidative injuries might be involved in the pathogenesis of dementia of Alzheimer’s type, as well as suggested that some antioxidant might be associated with the cognitive functions in dementia of Alzheimer’s type. (J Korean Neuropsychiatr Assoc 2006;45(4):357-362)
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