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경도인지장애와 알츠하이머형 치매 환자에서 혈중Superoxide Dismutase 활성도와 Nitric oxide 및 Homocysteine 농도

Blood Superoxide Dismutase Activity, Nitric Oxide and Homocysteine Concentrations in the Mild Cognitive Impairment and Alzheimer’s Dementia

박성우|김영훈|윤성욱|유영선|이선정|이정구|정성수|전동욱|김지은|신배섭|백준형
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2007.12|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제13권 제2호|pp. 275-282

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참고문헌

주제분류정신과학

초록

목 적 경도인지장애와 알츠하이머형 치매 환자에서 정상 대조군에 비해 혈중 Superoxide dismutase(SOD) 활성도와 nitric oxide(NO) 및 homocysteine 농도가 유의하게 차이가 나는지와 함께 전체 대상자에 대해 인지기능 저하 정도와 각각의 상관관계에 대해 알아보고자 하였다. 방 법 본 연구는 52명의 알츠하이머 치매 환자, 67명의 경도인지장애, 49명의 정상대조군을 대상으로 하였고 알츠하이머병의 진단은 DSM-IV와 NINCDS-ADRDA의 진단 기준을 따랐다. 인구학적 조사와 함께 임상적 평가로 Mini-Mental Status Examination-Korean ver-sion(MMSE-KC), Clin ical Dementia Rating Scale (CDRS), Geriatric Depression Scale(GDS-K)을 시행하였고, 혈장 SOD 활성도와 혈청 NO 농도 및 혈장 homocysteine 농도를 측정하여 분석하였다.

Abstract

Objectives：The purpose of this study was to investigate the differences in the blood superoxide dismutase(SOD) activity, concentrations of nitric oxide(NO) and homocysteine between the normal controls, mild cognitive impairment(MCI) and Alzheimer’s dementia. And we also evaluate the correlation between blood SOD activity, concentrations of NO and homocysteine and the cognitive decline level among all subjects. Methods：The study was carried out in 52 patients with Alzheimer’s dementia, 67 subjects with MCI and 49 normal controls. The subject received a diagnosis of Alzheimer’s dementia based on DSM-IV and NINCDS-ADRDA criteria. The Subjects were evaluated the demographic data and clinical data, including the Mini-Mental Status Examination-Korean version(MMSE-KC), clinical dementia rating scale(CDRS) and Geriatric Depression Scale(GDS-K). Plasma SOD activity, serum NO concentration and plasma homocysteine concentration were measured. Results：There was no significant correlation between the oxidative stress, such as blood SOD activity, concentrations of NO and homocysteine in the subjects with MCI and Alzheimer’s dementia, when compared with the normal controls. There was a weak negative correlation between the total score of MMSE-KC and plasma homocysteine level (r=-0.18；p<0.05). Conclusion：This study concluded that the plasma homocysteine level in mild Alzheimer’s dementia could be a more useful biological marker to estimate the cognitive decline compared to blood SOD activity and NO concentration.

참고문헌 (44)

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