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알츠하이머형치매 환자에서 혈중 총항산화력 저하에 영향미치는 인자

Factors Influencing on the Decreased Blood Total Antioxidant Capacity in Patients with Dementia of the Alzheimer’s Type

변현우|전진숙|김인성
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2008.12|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제14권 제2호|pp. 194-200

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키워드

연령교육수준AgeEducation level알츠하이머형치매총항산화력정상노인대조군한국형간이정신상태검사Dementia of the Alzheimer’s typeTotal antioxidant capacityNormal aged controlMini-mental state examination-Korean version
주제분류정신과학

초록

알츠하이머치매에서 혈중 총항산화력에 영향미치는 요인을 알아보기 위해서, 알츠하이머형치매 환자 65명(남자 19명, 여자 46명)과 정상노인대조군 58명(남자 17명, 여자 41명)을 대상으로 구조적 면담과 여러 평가도구를 사용한 치매평가(MMSE-K, CDR, GDS, ADL), 화학발광법으로 혈중 총항산화력을 측정하여 다음의 결과를 얻었다. 1) 알츠하이머치매군의 혈중 총항산화력(1.7843±0.1366 mmol/L)은 정상노인군 (1.9267±0.1918 mmol/L) 보다 유의하게 낮았다(p<0.001). 2) 정상노인군에서 혈중 총항산화력은 연령에 역상관성(ρ=-0.399, p<0.005), 교육수준(ρ=0.547, p<0.001)과 MMSE-K 점수(ρ=0.925, p<0.001)에 순상관성을 보인 반면, 알츠하이머치매군에서 혈중 총항산화력은 순상관성을 보인 MMSE-K 점수(ρ=0.482, p<0.001)를 제외하곤 다른 요인에 무관하였다. 결론적으로, 말초 산화스트레스 지표의 일종인 혈중 총산화력의 측정은 알츠하이머치매에서 인지기능의 변화를 평가하고 이에 관련된 병태생리를 유추하는데 유용하게 사용될 수 있다.

Abstract

Objectives：The aims of this study are to investigate whether blood total antioxidant capacity(TAC) is decreased in dementia of the Alzheimer’s type(DAT), and to identify demographic and clinical factors related to TAC. Methods：Clinical assessments using the mini-mental state examination-Korean version(MMSE-K), clinical dementia rating(CDR), global deterioration scale(GDS), activities of daily living(ADL) and measurements of blood TAC using chemiluminescence were performed in 58 normal aged controls(17 males and 41 females) and 65(19 males and 46 females) patients with DAT. Results：1) The mean(±S.D.) blood TAC of the patients(1.7843±0.1366mmol/L) was significantly lower than that of normal aged controls(1.9267±0.1918mmol/L)(p<0.001). 2) In normal aged controls, blood TAC had negative rank correlation with age(ρ=-0.399, p<0.005), and had positive rank correlation with education level(ρ=0.547, p<0.001) and MMSE-K scores(ρ=0.925, p<0.001). In patients with DAT, blood TAC showed no rank correlation with those variables except MMSE-K scores(ρ=0.482, p<0.001). Conclusion：To measure blood TAC, a kind of peripheral marker of oxidative stress, seems to be useful to evaluate cognitive change and to speculate related pathophysiology.

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