주산기 백서에서 혈중 에스트로겐 농도와 공간 기억력과의 상관관계
Correlation between Serum Estrogen and Spatial Memory in Peripartal Rats
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초록
이번 연구 결과는 임신 3기부터 분만 4주 후동안 모리스 수중 미로에서 도피대를 찾는 시간으로 본 공간학습능력은 변화가 없으나, 출산 직후 에스트로겐 치가 빨리 감소하지 않거나, 산욕기에 에스트로겐 치 회복이 더디면 인지기능이 저하될 가능성을 시사한다.
Abstract
Objectives：This study was designed to find possible effect of pregnancy and parturition on spatial memory, especially in relation to levels of estrogen during the third trimester and postpartal period in rats. Methods：25 female Sprague Dawley rats were divided into pregnant group (N=14) and control group (N=11). Changes in spatial memory during 6 weeks including third trimester and postpartal period were measured using Morris water maze. Time to reach the platform in the maze was indicator of spatial memory. Serum estrogen level was measured on 1 week before delivery, postpartal day 1, and day 14. Results：Both groups showed gradual improvement in performance by trial days and weeks, but no significant difference was found between the two groups. However in the third trimester, pregnant group showed a trend of less achievement on 3 days of learning than control group. Serum estrogen levels did not differ significantly between groups over the 6 weeks of period. However there was positive correlation between serum estrogen level on postpartum day 1 and time to reach platform on postpartum week 2, and negative correlation between estrogen level on postpartum day 14 and latency to the platform on postpartum week 5. Conclusion：These results imply that changes in the serum estrogen level may have dual effects on the spatial learning in peripartal period. It is suggested that decline in cognitive function might occur either by failure of rapid decrease of estrogen, immediately after parturition, or retarded restoration of estrogen in later postpartal period. (J Korean Neuropsychiatr Assoc 2006; 45(5):453-458)
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