폐경기모델 백서 해마에서 식물성 에스트로젠에 의한 뇌-혈액장벽 유전자 occludin 발현의 변화
Change in the Expression of Occludin, a Gene for Blood-Brain Barrier by Phytoestrogens in Hippocampus of Rat Model for Menopause
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Abstract
- To elucidate the effect of phytoestrogens on the prevention of neurodegenerativedisease in postmenopausal women, the expression of occludin which build up the blood-brainbarrier was examined in hippocampus following oral administration of estrogen (E2), genistein,diadzein or combination of genistein and diadzein in ovariectomized (OVX) female rats. E2significantly increased occludin mRNA level in OVX rat hippocampus, suggesting that estrogen isa physiological regulator for structural integrity of the blood-brain barrier in hippocampus.hippocampus, suggesting that isoflavone diet may be effective for protection of structuralintegrity of blood-brain barrier in hippocampus from degenerative changes in estrogendeficiency.
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