남성화 암쥐의 모리스 수중 미로 수행력 : 성에 따른 공간기억력과 테스토스테론 효과의 차이
The Morris Water Maze Performance in Androgenized Female Rats : Sexual Dimorphisms in Spatial Memory and Effects of Testosterone
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초록
출생직후 테스토스테론에 노출시킨 암쥐는 숫쥐와 유사한 테스토스테론 의존형 공간학습구조가 발달한다고 제안한다.
Abstract
Objectives：It is widely accepted that gonadal steroids are involved in organization and activation of sexual dimorphism in the brain areas related with spatial learning. This study aimed to test the following hypothesis：1) spatial memory is affected by sex, 2) this difference is related with brain differentiation by exposure to testosterone in the neonatal period, and/or 3) the sexual difference of spatial memory is the result of the interaction between organization of sexual dimorphism in the brain and the circulating testosterone after growing up. Methods：Testosterone enanthate 100 μg (‘androgenized’) or vehicle (‘control’) was randomly administered to 28 female and 25 male rat pups within 24 hour of birth. The escape latencies (EL) in Morris water maze were measured in 15 and 16 week of age with vehicle (‘baseline’) and with 10 μmol/kg of testosterone (‘with testosterone’), respectively. Each session consisted of 10 trials, and means of the last 5 trials were analyzed. Results：The baseline EL of the males were significantly shorter than females regardless of neonatal exposure to testosterone. With testosterone, EL of the androgenized females were significantly shorter than control females and comparable to those of males. Conclusion：Neonatal exposure to testosterone in female rats may develop a tesosterone-dependent male-like spatial learning system. (J Korean Neuropsychiatr Assoc 2007;46(5):518-522)
참고문헌 (28)
- Neave N, "Sex diferences in cognition: The role of testosterone and sexual orientation", 41, pp.245~262 (1999)
- Rizk-Jackson AM, "Efects of sex objects recognition and spatial navigation in humans", 173, pp.181~190 (2006)
- Linn MC, "Petersen AC. Emergence and characterization of sex difer-ences in spatial ability", pp.1479~1498
- Greene RA, "The role of reproductive hormones in maintain-ing cognition", 29, pp.437~453 (2002)
- Wiliams CL, "Meck WH. Organizational efects of early gonadal secretions on sexual diferentiation in spatial memory. Behav Neurosci 1990", pp.84~97
- Sutcliffe JS, "Influence of gender on working and spatial memory in the novel object recognition task in the rat", 177, pp.17~125 (2007)
- Jonason Z, "Meta-analysis of sex diferences in rodent models of learning and memory: a review of behavioral and biological data", 28, pp.811~825 (2005)
- Silverman I, "The hunter-gatherer theory of sex dif-ferences in spatial abilities: data from 40 countries", 36, pp.261~268 (2007)
- Healy SD, "Braithwaite VA. Spatial working memory in rats no diferences between the sexes. Proc R Sci 19", pp.2303~2308
- Roof RL, "Gender diferences in Moris water maze perfor-mance depend on task parameters", 68, pp.81~86 (1999)
- Silverman I, "Eals M. Sex diferences in spatial abilities"
- Silverman I, "Evolved mechanisms underlying wayfinding: further studies on the hunter-gatherer theory of spatial sex diferences", 21, pp.201~213 (2000)
- Martin SJ, "The rodent hippocampus and spatial memory: from synapses to systems", 67, pp.401~431 (2007)
- "Olton DS. The function of septo-hipocampal connections in spatialy organized behavior. Ciba Found Symp 1977", pp.327~349
- Becker JT, "Breitinger ER. Cognitive mapping in rats the role of the hipocampal and frontal system in retention and reversal. Behav Brain Res 1981", pp.1~2
- Loy R, "Milner TA. Neonatal steroid treatment alters axonal sprouting in adult hippocampus sexualy dimorphic development of cholinergic target neurons. Birth Defects Orig Artic Ser 1983", pp.417~423
- Forgie ML, "Manipulation of gonadal hormones in neonatal rats alters the morphological response of cortical neurons to brain injury in adulthood", 117, pp.257~262 (2006)
- MacLusky NJ, "Efects of dehydroepiandroste-rone and flutamide on hippocampal CA1 spine synapse density in male and female rats: implications for the role of androgens in maintenance of hippocampal structure", 145, pp.4154~4161 (2004)
- Grimshaw GM, "Mental rotation at 7 years: re-lations with prenatal testosterone levels and spatial play experiences", 29, pp.85~100 (1995)
- Kritzer MF, "Gonadectomy impairs T-maze acquisition in adult male rats", 39, pp.167~174 (2001)
- Isgor C, "Efects of neonatal gonadal steroids on adult CA3 pyramidal neuron dendritic morphology and spatial memory in rats", 55, pp.179~190 (2003)
- Isgor C, "Prenatal gonadal steroids afect adult spatial behavior, CA1 and CA3 pyramidal cel morphology in rats", 34, pp.183~198 (1998)
- Martin S, "Impaired spatial reference memory in aromatase-deficient (ArKO) mice", 14, pp.1979~1982 (2003)
- Sandstrom NJ, "Testosterone modulates per-formance on a spatial working memory task in male rats", 50, pp.18~26 (2006)
- Anderson MD, "Efect of androgen administration during puberty on hepatic CYP2C11, CYP3A, and CYP2A1 expression in adult female rats", 26, pp.1031~1038 (1998)
- Tabori NE, "Ultrastructural evidence that androgen receptors are located at extranuclear sites in the rat hippocampal formation", 130, pp.151~163 (2005)
- Nakamura N, "Effects of gonadectomy on immunoreactivity for choline acetyltransferase in the cortex, hippocampus,and basal forebrain of adult male rats", 109, pp.473~485 (2002)
- Moradpour F, "Anastrozole improved testosterone-induced impairment acquisition of spatial learning and memory in the hippocampal CA1 region in adult male rats", 175, pp.223~232 (2006)